Reactome | MX1 [cytosol]

MX1 [cytosol]

Stable Identifier

R-HSA-947489

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MXB, Interferon-induced GTP-binding protein Mx1, MX1_HUMAN

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External Reference Information

External Reference

UniProt:P20591 MX1

Gene Names

MX1

Chain

initiator methionine:1, chain:1-662, chain:2-662

Reference Genes

BioGPS Gene:4599 MX1

COSMIC (genes):MX1 MX1

CTD Gene:4599 MX1

dbSNP Gene:4599 MX1

ENSEMBL:ENSG00000157601 MX1

HGNC:7532 MX1

KEGG Gene (Homo sapiens):4599 MX1

Monarch:4599 MX1

NCBI Gene:4599 MX1

OMIM:147150 MX1

UCSC:P20591 MX1

Reference Transcript

Other Identifiers

0001410301

11716167_a_at

16923031

202086_at

37014_at

3922056

3922098

3922099

3922101

3922102

3922103

3922105

3922106

3922107

3922109

3922113

3922114

3922120

3922121

3922123

3922125

3922126

3922127

3922128

3922129

3922130

3922131

3922135

3922137

3922140

3922143

3922144

3922147

3922149

3922150

3922151

3922153

3922154

8068713

A_23_P17663

GE79032

GO:0000166

GO:0000266

GO:0002376

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005737

GO:0005739

GO:0005783

GO:0005789

GO:0005829

GO:0005856

GO:0005886

GO:0006810

GO:0006915

GO:0006950

GO:0006952

GO:0007005

GO:0007165

GO:0008017

GO:0008092

GO:0008150

GO:0008219

GO:0009615

GO:0014069

GO:0015031

GO:0015630

GO:0016020

GO:0016185

GO:0016192

GO:0030424

GO:0031410

GO:0031623

GO:0031965

GO:0031966

GO:0034340

GO:0042802

GO:0043167

GO:0043197

GO:0043226

GO:0044327

GO:0044403

GO:0045071

GO:0045087

GO:0045202

GO:0045211

GO:0048285

GO:0048471

GO:0050803

GO:0051607

GO:0060337

GO:0061024

GO:0061025

GO:0098793

GO:0098844

GO:0098884

ILMN_1662358

M33882_at

PH_hs_0025534

TC21000189.hg

TC21000739.hg

g4505290_3p_at

Participant Of

hasMember

Mx GTPases [cytosol]

Inferred To

Homologues of MX1 [cytosol] (Plasmodium falciparum)

MX1 [cytosol] (Bos taurus)

MX1 [cytosol] (Canis familiaris)

MX1 [cytosol] (Plasmodium falciparum)

MX1 [cytosol] (Sus scrofa)

Mx2 [cytosol] (Mus musculus)

Mx2 [cytosol] (Rattus norvegicus)

dyn-1 [cytosol] (Caenorhabditis elegans)

mxe [cytosol] (Danio rerio)

Mx [cytosol] (Gallus gallus)

dlpC [cytosol] (Dictyostelium discoideum)

shi [cytosol] (Drosophila melanogaster)

mx1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011527870.1, XP_005261039.1, NP_001269849.1, XP_016883838.1, NP_001171517.1, XP_005261037.1, XP_005261035.1, NP_002453.2, NP_001138397.1, XP_016883839.1, XP_005261038.1, XP_005261036.1

OpenTargets

ENSG00000157601

GeneCards

P20591

HPA

ENSG00000157601-MX1

Ensembl

ENSP00000381599, ENSP00000478441, ENST00000398600, ENSP00000410523, ENST00000398598, ENST00000455164, ENSG00000157601, ENST00000619682, ENSP00000381601

PRO

P20591

PDB

4P4U, 3LJB, 3SZR, 4P4T, 4P4S, 3ZYS, 5GTM

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q13507 TRPC3	1	TRPC3(1-848) [plasma membrane] (R-HSA-426172)	0.524	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2