Exchange of oxygen with sulfur in MoCo

Stable Identifier
R-HSA-947499
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

While the biosynthesis of the molybdenum cofactor for sulfite oxidase is finished after molybdenum ion insertion, human xanthine oxidase and aldehyde oxidase will only show activity with this cofactor when one of the oxygens bound to molybdenum is replaced with sulfur. The exchange is catalyzed by the MOCOS cysteine desulfurase (Ichida et al, 2001).

Literature References
PubMed ID Title Journal Year
11302742 Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II

Ichida, K, Matsumura, T, Sakuma, R, Hosoya, T, Nishino, T

Biochem Biophys Res Commun 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Mo-molybdopterin cofactor sulfurase activity of MOCOS:PXLP [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed