PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3

Stable Identifier
R-HSA-947514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In order to get a sulfur atom for subsequent sulfuration reactions, cysteine is first desulfurated by NFS1 which transfers it onto a cysteine of MOCS3, yielding a protein persulfide (Marelja et al, 2008).

Literature References
PubMed ID Title Journal Year
18650437 A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

Marelja, Z, Stöcklein, W, Nimtz, M, Leimkühler, S

J Biol Chem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine desulfurase activity of PXLP-K258-NFS1-2 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created