Reactome | Molybdenum ion transfer onto molybdopterin

Molybdenum ion transfer onto molybdopterin

Stable Identifier

R-HSA-947531

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Molybdenum ion transfer onto molybdopterin

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Gephyrin, which stabilizes receptors on neuronal membranes, also catalyzes the transfer of a molybdenum ion onto the cofactor. The mechanism was elucidated in plants but, as the pathway is highly conserved, human gephyrin can complement missing plant proteins. Doubts remain about the actual molybdenum donor, probably molybdate, and whether a copper ion is possibly bound and removed (Stallmeyer et al, 1999).

Literature References

PubMed ID	Title	Journal	Year
9990024	The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells Nerlich, A, Schwarz, G, Stallmeyer, B, Reiss, J, Kirsch, J, Mendel, RR, Schulze, J	Proc Natl Acad Sci U S A	1999