Cyclisation of GTP to precursor Z

Stable Identifier
R-HSA-947535
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GTP cyclizes in a reaction involving radicals of S-adenosylmethionine, catalyzed by the iron-sulfur cluster dimeric MOCS1. The intermediate result is called precursor Z (Hanzelmann et al, 2002; Hanzelmann et al, 2004).

Literature References
PubMed ID Title Journal Year
15180982 Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis

Hänzelmann, P, Hernández, HL, Menzel, C, Garcia-Serres, R, Huynh, BH, Johnson, MK, Mendel, RR, Schindelin, H

J Biol Chem 2004
11891227 Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis

Hänzelmann, P, Schwarz, G, Mendel, RR

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
S-adenosyl-L-methionine binding activity of holo-MOCS1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created