Transfer of sulfur from MOCS3-S-S onto MOCS2A

Stable Identifier
R-HSA-947538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transfer of sulfur from MOCS3-S-S onto MOCS2A
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sulfur transfer onto MOCS2A is closely preceded by its adenylylation and deadenylylation. After release of MOCS2A-CO-S(1-), two cysteines on MOCS3 form a disulfide bridge. This means that MOCS3 has to be reduced to be able to participate in the next round. The reducing agent is not known (Marelja et al, 2008).
Literature References
PubMed ID Title Journal Year
18650437 A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

Leimkühler, S, Nimtz, M, Stöcklein, W, Marelja, Z

J Biol Chem 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

sulfurtransferase activity of MOCS3-S-S(1-):Zn2+ [cytosol]

Physical Entity
MOCS3-S-S(1-):Zn2+ [cytosol] (Homo sapiens)
Activity
sulfurtransferase activity (GO:0016783)
Authored
Stephan, R  (2010-09-05)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-09-08)
Cite Us!