Reactome | PSME4 [cytosol]

PSME4 [cytosol]

Stable Identifier

R-HSA-947606

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome activator complex subunit 4, PSME4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14997 PSME4

Gene Names

PSME4, KIAA0077, KIAA0077

Chain

chain:1-1843

Reference Genes

BioGPS Gene:23198 PSME4

COSMIC (genes):PSME4 PSME4

CTD Gene:23198 PSME4

dbSNP Gene:23198 PSME4

ENSEMBL:ENSG00000068878 PSME4

HGNC:20635 PSME4

Monarch:23198 PSME4

NCBI Gene:23198 PSME4

OMIM:607705 PSME4

UCSC:Q14997 PSME4

Reference Transcript

RefSeq:NM_014614.2 PSME4

Other Identifiers

11717864_a_at

11717865_at

11717866_s_at

11751884_s_at

11751885_x_at

11755120_a_at

16897560

212219_PM_at

212219_at

212220_PM_at

212220_at

212222_PM_at

212222_at

23198

2553269

2553270

2553271

2553281

2553283

2553284

2553285

2553286

2553288

2553289

2553290

2553293

2553294

2553295

2553296

2553297

2553298

2553299

2553300

2553301

2553302

2553303

2553304

2553306

2553307

2553308

2553309

2553310

2553311

2553312

2553313

2553314

2553315

2553316

2553317

2553318

2553319

2553320

2553321

2553325

2553326

2553328

2553329

2553330

2553331

2553332

2553333

2553334

2553335

2553336

2553338

2553339

2553340

2553341

2553343

2553344

2553345

2553346

2553347

2553348

2553349

2553352

2553355

2553356

2553357

2553358

2553366

2553367

36978_at

50785_at

8052149

A_23_P79628

A_33_P3243997

A_33_P3361472

D38521_at

GE57189

GO:0000502

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006325

GO:0006974

GO:0007283

GO:0010499

GO:0016504

GO:0016607

GO:0022414

GO:0030154

GO:0030163

GO:0035092

GO:0042393

GO:0043226

GO:0070577

GO:0070628

GO:0098772

GO:1990111

HMNXSV003000039

HMNXSV003009591

Hs.112396.0.S1_3p_at

Hs.112396.0.S2_3p_at

Hs.112396.0.S3_3p_at

ILMN_1763540

PH_hs_0040855

TC02001848.hg

Participates

as a component of

Spermatoproteasome [cytosol] (Homo sapiens)

as an input of

Formation of the spermatoproteasome (Homo sapiens)

Cross References

ENSEMBL

ENST00000404125, ENSP00000384211

OpenTargets

ENSG00000068878

HPA

ENSG00000068878-PSME4

PRO

Q14997

Pharos - Targets

Q14997

GlyGen

Q14997

PDB

6REY, 8CVS, 7NAQ, 6KWX, 6KWY

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.725	5
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.643	5
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.643	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.643	5
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.643	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.564	2
UniProt:Q86Y26 NUTM1			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.527	2
UniProt:Q6JEL2 KLH10			0.527	3
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.527	2
UniProt:Q9BQ83 SLX1A	1	SLX1A [nucleoplasm] (R-HSA-5686481)	0.527	2
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.527	5
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.527	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.527	4
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.527	3
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.527	5
UniProt:P14324 FDPS	1	FDPS [cytosol] (R-HSA-981566)	0.527	2

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