Reactome | UBA3 [cytosol]

UBA3 [cytosol]

Stable Identifier

R-HSA-947632

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD8-activating enzyme E1 catalytic subunit, UBA3_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P02649

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External Reference Information

External Reference

UniProt:Q8TBC4 UBA3

Gene Names

UBA3, UBE1C

Chain

initiator methionine:, chain:2-463

Reference Genes

BioGPS Gene:9039 UBA3

COSMIC (genes):UBA3 UBA3

CTD Gene:9039 UBA3

dbSNP Gene:9039 UBA3

ENSEMBL:ENSG00000144744 UBA3

ENSEMBL_homo_sapiens_GENE:ENSG00000144744.18 UBA3

HGNC:12470 UBA3

KEGG Gene (Homo sapiens):9039 UBA3

Monarch:9039 UBA3

NCBI Gene:9039 UBA3

OMIM:603172 UBA3

UCSC:Q8TBC4 UBA3

Reference Transcript

Other Identifiers

11730728_a_at

16956055

209115_PM_at

209115_at

2681196

2681197

2681198

2681199

2681200

2681201

2681203

2681205

2681207

2681208

2681210

2681212

2681215

2681216

2681217

2681218

2681219

2681221

2681224

2681225

2681228

2681230

2681235

2681238

40066_at

8088718

9039

A_23_P211840

GE54399

GO:0000166

GO:0000278

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006508

GO:0007049

GO:0007113

GO:0008641

GO:0016740

GO:0016874

GO:0019781

GO:0019788

GO:0032991

GO:0036211

GO:0042802

GO:0043226

GO:0043687

GO:0045116

GO:0046982

GO:0051726

GO:0140096

GO:0140657

HMNXSV003011768

ILMN_1689142

ILMN_2324157

PH_hs_0029245

TC03001538.hg

g5912116_3p_at

Participates

as a component of

UBA3:NAE1 [cytosol] (Homo sapiens)

as an output of

SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)

as an input of

SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)

as a candidate of

Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)

Other forms of this molecule

G76-NEDD8-C237-UBA3 [cytosol]

Inferred To

UBA3 [cytosol] (Bos taurus)

UBA3 [cytosol] (Caenorhabditis elegans)

UBA3 [cytosol] (Canis familiaris)

UBA3 [cytosol] (Danio rerio)

UBA3 [cytosol] (Dictyostelium discoideum)

UBA3 [cytosol] (Drosophila melanogaster)

UBA3 [cytosol] (Gallus gallus)

UBA3 [cytosol] (Mus musculus)

UBA3 [cytosol] (Plasmodium falciparum)

UBA3 [cytosol] (Rattus norvegicus)

UBA3 [cytosol] (Saccharomyces cerevisiae)

UBA3 [cytosol] (Schizosaccharomyces pombe)

UBA3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_937838.1, NP_003959.3

OpenTargets

ENSG00000144744

HPA

ENSG00000144744-UBA3

GeneCards

Q8TBC4

Ensembl

ENST00000361055, ENST00000349511, ENSP00000354340, ENSP00000340041, ENSG00000144744

PRO

Q8TBC4

Pharos - Targets

Q8TBC4

PDB

1R4N, 1YOV, 3GZN, 3DBL, 3FN1, 1TT5, 3DBR, 2NVU, 5JJM, 1Y8X, 2LQ7, 3DBH, 1R4M

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14732 IMPA2	1	IMPA2 [cytosol] (R-HSA-1604572)	0.718	6
UniProt:Q96FN4 CPNE2			0.718	6
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.704	3
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.666	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.564	6
UniProt:Q13564 NAE1	1	NAE1 [cytosol] (R-HSA-8951449)	0.556	3
UniProt:Q9BVJ7 DUS23			0.556	3
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) APOE-4 [extracellular region] (R-HSA-9711070) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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