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GHSR [plasma membrane]
Stable Identifier
R-HSA-947659
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Growth hormone secretagogue receptor type 1, GHSR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
GHSR is a receptor for ghrelin (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
GHSR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92847 GHSR
Gene Names
GHSR
Chain
chain:1-366
Reference Genes
BioGPS Gene:2693 GHSR
COSMIC (genes):GHSR GHSR
CTD Gene:2693 GHSR
dbSNP Gene:2693 GHSR
ENSEMBL:ENSG00000121853 GHSR
ENSEMBL_homo_sapiens_GENE:ENSG00000121853.4 GHSR
HGNC:4267 GHSR
KEGG Gene (Homo sapiens):2693 GHSR
Monarch:2693 GHSR
NCBI Gene:2693 GHSR
OMIM:601898 GHSR
UCSC:Q92847 GHSR
Reference Transcript
RefSeq:NM_004122.2 GHSR
RefSeq:NM_198407.2 GHSR
Other Identifiers
11736795_a_at
16961610
221360_PM_s_at
221360_s_at
224554_PM_at
224554_at
237101_PM_at
237101_at
2693
2705691
2705692
2705693
2705694
2705695
2705696
2705697
74550_at
8092165
A_23_P109864
A_33_P3261620
GE510426
GE81352
GO:0001616
GO:0003012
GO:0004930
GO:0005515
GO:0005886
GO:0006629
GO:0006954
GO:0007010
GO:0007165
GO:0007186
GO:0007283
GO:0007565
GO:0007611
GO:0008154
GO:0008343
GO:0009725
GO:0009755
GO:0009986
GO:0010700
GO:0012501
GO:0016020
GO:0016520
GO:0017046
GO:0022414
GO:0022600
GO:0023052
GO:0030252
GO:0032094
GO:0032099
GO:0032100
GO:0032354
GO:0032355
GO:0032691
GO:0032715
GO:0032720
GO:0032869
GO:0034330
GO:0036321
GO:0040018
GO:0042562
GO:0042802
GO:0043005
GO:0043134
GO:0043568
GO:0045121
GO:0045923
GO:0045927
GO:0046676
GO:0046697
GO:0048009
GO:0048856
GO:0050728
GO:0050877
GO:0051963
GO:0051969
GO:0060089
GO:0060123
GO:0060259
GO:0060416
GO:0071222
GO:0071548
GO:0090327
GO:0097060
GO:0097067
GO:0098685
GO:0098696
GO:0098794
GO:0098978
GO:0099170
GO:0099175
GO:0120058
GO:1902065
GO:1903672
GO:1904000
GO:1904349
GO:1905333
GO:1905564
GO:1990314
GO:2000110
HMNXSV003007416
Hs.130212.0.S1_3p_at
ILMN_1717492
ILMN_1806691
PH_hs_0007660
PH_hs_0013148
TC03002005.hg
g1504140_3p_at
g4758433_3p_a_at
Participates
as an input of
GHSR is a receptor for ghrelin (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
Inferred To
GHSR [plasma membrane]
(Bos taurus)
GHSR [plasma membrane]
(Caenorhabditis elegans)
GHSR [plasma membrane]
(Canis familiaris)
GHSR [plasma membrane]
(Gallus gallus)
GHSR [plasma membrane]
(Sus scrofa)
PK2-R1 [plasma membrane]
(Drosophila melanogaster)
ghsr [plasma membrane]
(Xenopus tropicalis)
nmur-1 [plasma membrane]
(Caenorhabditis elegans)
nmur-2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of GHSR [plasma membrane]
(Caenorhabditis elegans)
Homologues of GHSR [plasma membrane]
(Drosophila melanogaster)
Homologues of GHSR [plasma membrane]
(Sus scrofa)
npr-20 [plasma membrane]
(Caenorhabditis elegans)
Ghsr [plasma membrane]
(Mus musculus)
Ghsr [plasma membrane]
(Rattus norvegicus)
PK1-R [plasma membrane]
(Drosophila melanogaster)
CapaR [plasma membrane]
(Drosophila melanogaster)
PK2-R2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_940799.1
,
NP_004113.1
ZINC - World Drugs
GHSR_HUMAN
Guide to Pharmacology - Targets
246
OpenTargets
ENSG00000121853
ZINC - Substances
GHSR_HUMAN
ZINC target
Q92847
PRO
Q92847
PDB
7NA7
,
7F9Z
,
7NA8
,
7F9Y
,
6KO5
,
7W2Z
ZINC - Investigational
GHSR_HUMAN
HPA
ENSG00000121853-GHSR
GeneCards
Q92847
Ensembl
ENST00000241256
,
ENSG00000121853
,
ENST00000427970
,
ENSP00000395344
,
ENSP00000241256
Pharos - Targets
Q92847
ZINC - Predictions - Purchasable
GHSR_HUMAN
Orphanet
18439
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