Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MCHR1 [plasma membrane]
Stable Identifier
R-HSA-947682
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Melanin-concentrating hormone receptor 1, MCHR1_HUMAN
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
BBSome-mediated cargo-targeting to cilium (Homo sapiens)
ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Melanin-concentrating hormone receptors bind MCH (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
MCHR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99705 MCHR1
Gene Names
MCHR1, GPR24, SLC1
Chain
chain:1-353
Reference Genes
BioGPS Gene:2847 MCHR1
COSMIC (genes):MCHR1 MCHR1
CTD Gene:2847 MCHR1
dbSNP Gene:2847 MCHR1
ENSEMBL:ENSG00000128285 MCHR1
ENSEMBL_homo_sapiens_GENE:ENSG00000128285.5 MCHR1
HGNC:4479 MCHR1
KEGG Gene (Homo sapiens):2847 MCHR1
Monarch:2847 MCHR1
NCBI Gene:2847 MCHR1
OMIM:601751 MCHR1
UCSC:Q99705 MCHR1
Reference Transcript
RefSeq:NM_005297.3 MCHR1
Other Identifiers
11725147_at
11756848_a_at
16930486
221354_PM_s_at
221354_s_at
223855_PM_s_at
223855_s_at
230498_PM_at
230498_at
2847
3946496
3946497
3946498
3946499
3946500
54517_at
8073296
A_14_P117741
A_23_P211543
A_33_P3393311
GE59374
GO:0004930
GO:0005102
GO:0005886
GO:0005929
GO:0006091
GO:0007165
GO:0007166
GO:0007186
GO:0007193
GO:0007204
GO:0007218
GO:0007631
GO:0008188
GO:0016020
GO:0023052
GO:0030273
GO:0042562
GO:0042923
GO:0043005
GO:0043226
GO:0051928
GO:0060089
GO:0060170
GO:0097730
HMNXSV003026301
Hs.248122.1.S1_3p_at
ILMN_1685096
PH_hs_0013152
TC22000326.hg
U71092_at
g12804624_3p_a_at
g4885312_3p_a_at
Participates
as a candidate of
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
as a member of
MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
MCHR1 [ciliary membrane]
Inferred To
npr-16 [plasma membrane]
(Caenorhabditis elegans)
npr-26 [plasma membrane]
(Caenorhabditis elegans)
AstC-R1 [plasma membrane]
(Drosophila melanogaster)
MCHR1 [plasma membrane]
(Bos taurus)
MCHR1 [plasma membrane]
(Caenorhabditis elegans)
MCHR1 [plasma membrane]
(Canis familiaris)
MCHR1 [plasma membrane]
(Sus scrofa)
AstC-R2 [plasma membrane]
(Drosophila melanogaster)
mchr1.2 [plasma membrane]
(Xenopus tropicalis)
npr-23 [plasma membrane]
(Caenorhabditis elegans)
Rh7 [plasma membrane]
(Drosophila melanogaster)
npr-24 [plasma membrane]
(Caenorhabditis elegans)
npr-28 [plasma membrane]
(Caenorhabditis elegans)
npr-18 [plasma membrane]
(Caenorhabditis elegans)
Mchr1 [plasma membrane]
(Mus musculus)
Mchr1 [plasma membrane]
(Rattus norvegicus)
Homologues of MCHR1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of MCHR1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005288.3
Guide to Pharmacology - Targets
280
OpenTargets
ENSG00000128285
ZINC - Substances
MCHR1_HUMAN
ZINC target
Q99705
PRO
Q99705
ZINC - Investigational
MCHR1_HUMAN
HPA
ENSG00000128285-MCHR1
GeneCards
Q99705
Ensembl
ENST00000249016
,
ENSG00000128285
,
ENSP00000249016
Pharos - Targets
Q99705
ZINC - Predictions - Purchasable
MCHR1_HUMAN
HMDB Protein
HMDBP13925
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text