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UBA2 [nucleoplasm]
Stable Identifier
R-HSA-947696
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUMO-activating enzyme subunit 2, SAE2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
Processing and activation of SUMO (Homo sapiens)
SUMO is conjugated to E1 (UBA2:SAE1) (Homo sapiens)
Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
UBA2:SAE1 [nucleoplasm] (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
UBA2:SAE1 [nucleoplasm] (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
UBA2:SAE1 [nucleoplasm] (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Homo sapiens)
Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)
UBA2:SAE1 [nucleoplasm] (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
Transfer of SUMO2 from E1 to UBE2I (UBC9) (Homo sapiens)
UBA2:SAE1 [nucleoplasm] (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)
UBA2:SAE1 [nucleoplasm] (Homo sapiens)
UBA2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11481243
Expression and regulation of the mammalian SUMO-1 E1 enzyme
Azuma, Y
,
Tan, SH
,
Cavenagh, MM
,
Ainsztein, AM
,
Saitoh, H
,
Dasso, M
FASEB J.
2001
External Reference Information
External Reference
UniProt:Q9UBT2 UBA2
Gene Names
UBA2, SAE2, UBLE1B, HRIHFB2115
Chain
chain:1-640
Reference Genes
BioGPS Gene:10054 UBA2
COSMIC (genes):UBA2 UBA2
CTD Gene:10054 UBA2
dbSNP Gene:10054 UBA2
ENSEMBL:ENSG00000126261 UBA2
HGNC:30661 UBA2
KEGG Gene (Homo sapiens):10054 UBA2
Monarch:10054 UBA2
NCBI Gene:10054 UBA2
OMIM:613295 UBA2
UCSC:Q9UBT2 UBA2
Reference Transcript
RefSeq:NM_005499.2 UBA2
Other Identifiers
0005420088
10054
11717530_a_at
11717531_x_at
11749584_a_at
11758626_s_at
16860746
1Y8Q
1Y8R
201177_s_at
229587_at
2345219
2928376
2928377
2928378
2928380
2PX9
34814_at
3829769
3829770
3829771
3829773
3829774
3829777
3829778
3829780
3829787
3829788
3829790
3829791
3829792
3829793
3829795
3829798
3829800
3829804
3829808
3829809
3829810
3829811
3829812
3829813
3829814
3KYC
3KYD
41436
4W5V
5FQ2
74323_at
8027650
A_24_P376229
A_24_P926935
AAC99992
AAD12784
AAD23914
AAD24434
AAH03153
AAP88783
AB015337
AB208872
AC008747
AF079566
AF090384
AF110957
AK124730
AL136905
BAA34795
BAD92109
BAG54081
BC003153
BT009781
CAB66839
CAG33037
CCDS12439
CR456756
ENSG00000126261
ENSP00000246548
ENSP00000437484
ENST00000246548
ENST00000246548.8
ENST00000439527
ENST00000439527.6
EntrezGene:10054
EntrezGene:UBA2
g4885648_3p_a_at
g4885648_3p_x_at
GE79556
GO:0000166
GO:0000287
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0006464
GO:0008047
GO:0008134
GO:0008150
GO:0008641
GO:0016740
GO:0016874
GO:0016925
GO:0019899
GO:0019948
GO:0030234
GO:0031510
GO:0032182
GO:0032183
GO:0032446
GO:0032991
GO:0043085
GO:0043167
GO:0043226
GO:0044388
GO:0044390
GO:0046872
GO:0046982
HGNC:30661
HPA041436
Hs.4311.1.A1_3p_at
ILMN_1694085
ILMN_1742872
IPR000594
IPR018074
IPR023318
IPR028077
IPR030661
IPR032426
IPR033127
IPR035985
K7EPL2
K7ES38
MIM:613295
NM_005499
NP_005490
PF00899
PF14732
PF16195
PH_hs_0028596
PH_hs_0040878
TC19000444.hg
U35832
U3KQ55
U3KQ93
UBA2
UBA2-201
UBA2-202
UPI000004F09F
UPI0000E25113
XM_005258404
XM_006722962
XM_011526304
XM_017026134
XM_024451305
XP_005258461
XP_006723025
XP_011524606
XP_016881623
XP_024307073
XR_001753571
XR_935712
Participant Of
hasComponent
UBA2:SAE1 [nucleoplasm]
Other forms of this molecule
SUMO3-C173-UBA2 [nucleoplasm]
SUMO2-C173-UBA2 [nucleoplasm]
SUMO1-C173-UBA2 [nucleoplasm]
Inferred To
UBA2 [nucleoplasm] (Bos taurus)
UBA2 [nucleoplasm] (Caenorhabditis elegans)
UBA2 [nucleoplasm] (Canis familiaris)
UBA2 [nucleoplasm] (Danio rerio)
UBA2 [nucleoplasm] (Dictyostelium discoideum)
UBA2 [nucleoplasm] (Drosophila melanogaster)
UBA2 [nucleoplasm] (Gallus gallus)
UBA2 [nucleoplasm] (Mus musculus)
UBA2 [nucleoplasm] (Plasmodium falciparum)
UBA2 [nucleoplasm] (Rattus norvegicus)
UBA2 [nucleoplasm] (Saccharomyces cerevisiae)
UBA2 [nucleoplasm] (Schizosaccharomyces pombe)
UBA2 [nucleoplasm] (Sus scrofa)
UBA2 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_005490.1
OpenTargets
ENSG00000126261
GeneCards
Q9UBT2
PRO
Q9UBT2
HMDB Protein
HMDBP09256
PDB
5FQ2
,
2PX9
,
4W5V
,
6CWY
,
3KYC
,
3KYD
,
1Y8Q
,
1Y8R
,
6CWZ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63279 UBE2I
8
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
0.806
7
UniProt:P63165 SUMO1
155
TOPORS-G97-SUMO1 [nucleoplasm]
(R-HSA-4551623)
K14-UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-4085334)
PIAS4-G97-SUMO1 [nucleoplasm]
(R-HSA-3968375)
K2592-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551627)
K2723-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551737)
K2650-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551591)
K196-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551630)
K171-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551632)
K159-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551713)
MDM-G97-SUMO1 [nucleoplasm]
(R-HSA-3730829)
K575-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090305)
K804-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782561)
K750-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090298)
K676-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090396)
K554-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782555)
K779-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782585)
ING2-G97-SUMO1 [nucleoplasm]
(R-HSA-4086096)
K788-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085297)
K731-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085312)
K239-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085320)
K239-NCOA2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085299)
K731-NCOA2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085290)
K788-NCOA2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085308)
NPM1-G97-SUMO1 [nucleoplasm]
(R-HSA-4086019)
NCOR2-G97-SUMO1 [nucleoplasm]
(R-HSA-3927883)
DDX17-G97-SUMO1 [nucleoplasm]
(R-HSA-3900210)
PARK7-G97-SUMO1 [nucleoplasm]
(R-HSA-4085344)
K1033-CREBBP-G97-SUMO1 [nucleoplasm]
(R-HSA-3927910)
K1056-CREBBP-G97-SUMO1 [nucleoplasm]
(R-HSA-3927954)
K998-CREBBP-G97-SUMO1 [nucleoplasm]
(R-HSA-3927822)
K1154-NRIP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4086067)
K756-NRIP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4086034)
DDX5-G97-SUMO1 [nucleoplasm]
(R-HSA-3900212)
CASP8AP2-G97-SUMO1 [nucleoplasm]
(R-HSA-3927863)
K1024-EP300-G97-SUMO1 [nucleoplasm]
(R-HSA-3899298)
K1020-EP300-G97-SUMO1 [nucleoplasm]
(R-HSA-3899290)
CTBP1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730764)
K231-SAFB-G97-SUMO1 [nucleoplasm]
(R-HSA-4085364)
K294-SAFB-G97-SUMO1 [nucleoplasm]
(R-HSA-4085341)
K624-MKL1-G97-SUMO1 [nucleoplasm]
(R-HSA-3900128)
K576-MKL1-G97-SUMO1 [nucleoplasm]
(R-HSA-3900225)
K499-MKL1-G97-SUMO1 [nucleoplasm]
(R-HSA-3900219)
K631-DAXX-G97-SUMO1 [nucleoplasm]
(R-HSA-4086044)
K630-DAXX-G97-SUMO1 [nucleoplasm]
(R-HSA-4086012)
SIN3A-G97-SUMO1 [nucleoplasm]
(R-HSA-4086058)
PPARGC1A-G97-SUMO1 [nucleoplasm]
(R-HSA-3903014)
HIPK2-G97-SUMO1 [nucleoplasm]
(R-HSA-4090362)
K774-NCOA1-G97-SUMO1 [nucleoplasm]
(R-HSA-4085292)
K732-NCOA1-G97-SUMO1 [nucleoplasm]
(R-HSA-4085278)
K538-MBD1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090416)
K499-MBD1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090332)
ZNF131-G97-SUMO1 [nucleoplasm]
(R-HSA-3730875)
K90-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755511)
K689-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755446)
K863-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755412)
K298-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755505)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
p-S172-IKBKE-G97-SUMO1 [nucleoplasm]
(R-HSA-4755408)
K309-IKBKG-G97-SUMO1 [nucleoplasm]
(R-HSA-4755404)
K277-IKBKG-G97-SUMO1 [nucleoplasm]
(R-HSA-4755531)
NFKBIA-G97-SUMO1 [nucleoplasm]
(R-HSA-4656987)
RANGAP1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730796)
AURKA-G97-SUMO1 [cytosol]
(R-HSA-4655413)
TOP2B-G97-SUMO1 [nucleoplasm]
(R-HSA-4641311)
TOP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4641306)
TOP2A-G97-SUMO1 [nucleoplasm]
(R-HSA-4641341)
K254-PCNA-G97-SUMO1 [nucleoplasm]
(R-HSA-4615853)
K-PCNA-G97-SUMO1 [nucleoplasm]
(R-HSA-4615836)
K164-PCNA-G97-SUMO1 [nucleoplasm]
(R-HSA-4615951)
MDC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4570527)
STAG2-G97-SUMO1 [nucleoplasm]
(R-HSA-3826645)
RAD21-G97-SUMO1 [nucleoplasm]
(R-HSA-3826574)
K411-RAD52-G97-SUMO1 [nucleoplasm]
(R-HSA-4568857)
K412-RAD52-G97-SUMO1 [nucleoplasm]
(R-HSA-4568850)
K414-RAD52-G97-SUMO1 [nucleoplasm]
(R-HSA-4568900)
XRCC4-G97-SUMO1 [nucleoplasm]
(R-HSA-4568869)
K160-PML-G97-SUMO1 [nucleoplasm]
(R-HSA-3730884)
K490-PML-G97-SUMO1 [nucleoplasm]
(R-HSA-3730833)
K65-PML-G97-SUMO1 [nucleoplasm]
(R-HSA-3730879)
K203-PARP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4551625)
K486-PARP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4551748)
K496-WRN-G97-SUMO1 [nucleoplasm]
(R-HSA-4568906)
K898-WRN-G97-SUMO1 [nucleoplasm]
(R-HSA-4568893)
K356-WRN-G97-SUMO1 [nucleoplasm]
(R-HSA-4568845)
RNF168-SUMO1 [nucleoplasm]
(R-HSA-4551631)
XPC-G97-SUMO1 [nucleoplasm]
(R-HSA-4570452)
TDG-G97-SUMO1 [nucleoplasm]
(R-HSA-4551682)
SP100-G97-SUMO1 [nucleoplasm]
(R-HSA-3730794)
BRCA1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730735)
RXRA-G97-SUMO1 [nucleoplasm]
(R-HSA-4341090)
NR5A2-G97-SUMO1 [nucleoplasm]
(R-HSA-4755424)
K386-AR-G97-SUMO1 [nucleoplasm]
(R-HSA-4090321)
K520-AR-G97-SUMO1 [nucleoplasm]
(R-HSA-4090352)
K293-NR3C1-G97-SUMO1 [nucleoplasm]
(R-HSA-4341110)
K277-NR3C1-G97-SUMO1 [nucleoplasm]
(R-HSA-4341057)
K389-THRA-G97-SUMO1 [nucleoplasm]
(R-HSA-4719415)
K283-THRA-G97-SUMO1 [nucleoplasm]
(R-HSA-4719434)
K399-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341020)
K428-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341035)
K494-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341093)
K89-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341058)
K119-NR5A1-G97-SUMO1 [nucleoplasm]
(R-HSA-4546379)
K194-NR5A1-G97-SUMO1 [nucleoplasm]
(R-HSA-4546380)
NR2C1-G97-SUMO1 [nucleoplasm]
(R-HSA-4717492)
K303-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090373)
K266-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090359)
K302-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090363)
K299-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090349)
K268-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090414)
K531-PGR-G97-SUMO1 [nucleoplasm]
(R-HSA-4341021)
K7-PGR-G97-SUMO1 [nucleoplasm]
(R-HSA-4341052)
K388-PGR-G97-SUMO1 [nucleoplasm]
(R-HSA-4341056)
K132-NR1H4-G97-SUMO1 [nucleoplasm]
(R-HSA-9610527)
NR1H4-G97-SUMO1 [nucleoplasm]
(R-HSA-4755434)
PPARG-G97-SUMO1 [nucleoplasm]
(R-HSA-4717445)
K395-PPARG-G97-SUMO1 [nucleoplasm]
(R-HSA-4717446)
PPARA-G97-SUMO1 [nucleoplasm]
(R-HSA-4341069)
K443-THRB-G97-SUMO1 [nucleoplasm]
(R-HSA-4719431)
K146-THRB-G97-SUMO1 [nucleoplasm]
(R-HSA-4719410)
K50-THRB-G97-SUMO1 [nucleoplasm]
(R-HSA-4719401)
RORA-G97-SUMO1 [nucleoplasm]
(R-HSA-4719426)
HIC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4570544)
TP53BP1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730731)
SP3-G97-SUMO1 [nucleoplasm]
(R-HSA-3730646)
K423-MITF-G97-SUMO1 [nucleoplasm]
(R-HSA-3730755)
K289-MITF-G97-SUMO1 [nucleoplasm]
(R-HSA-3730738)
K25-FOXL2-G97-SUMO1 [nucleoplasm]
(R-HSA-3968400)
K150-FOXL2-G97-SUMO1 [nucleoplasm]
(R-HSA-3968382)
K114-FOXL2-G97-SUMO1 [nucleoplasm]
(R-HSA-3968396)
HNRNPC-G97-SUMO1 [nucleoplasm]
(R-HSA-4570515)
K497-NOP58-G97-SUMO1 [nucleoplasm]
(R-HSA-4570504)
K467-NOP58-G97-SUMO1 [nucleoplasm]
(R-HSA-4570462)
DNMT3B-G97-SUMO1 [nucleoplasm]
(R-HSA-4655444)
DNMT3A-G97-SUMO1 [nucleoplasm]
(R-HSA-4655383)
DNMT1-G97-SUMO1 [nucleoplasm]
(R-HSA-4655358)
K84-CBX5-G97-SUMO1 [nucleoplasm]
(R-HSA-4615838)
K-CBX5-G97-SUMO1 [nucleoplasm]
(R-HSA-4615955)
K476-HDAC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4615867)
K444-HDAC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4616028)
CBX4-G97-SUMO1 [nucleoplasm]
(R-HSA-4551756)
HDAC2-G97-SUMO1 [nucleoplasm]
(R-HSA-4616032)
SUZ12-G97-SUMO1 [nucleoplasm]
(R-HSA-4615961)
SATB1-G97-SUMO1 [nucleoplasm]
(R-HSA-4615877)
HDAC4-G97-SUMO1 [nucleoplasm]
(R-HSA-4615956)
K1971-CHD3-G97-SUMO1 [nucleoplasm]
(R-HSA-8956370)
HIST1H4-G97-SUMO1 [nucleoplasm]
(R-HSA-4570549)
BMI1-G97-SUMO1 [nucleoplasm]
(R-HSA-4551654)
TFAP2B-G97-SUMO1 [nucleoplasm]
(R-HSA-3730839)
TFAP2C-G97-SUMO1 [nucleoplasm]
(R-HSA-3730823)
TFAP2A-1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730825)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
HERC2-SUMO1 [nucleoplasm]
(R-HSA-4551761)
0.795
7
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