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p-T250,T255,T385,S437-MKNK1 [cytosol]
Stable Identifier
R-HSA-947860
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S437,T250,T255,T385-MKNK1, p- MNK1
Locations in the PathwayBrowser for interactor UniProt:Q96CV9
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
p-T250,T255,T385,S437-MKNK1 [cytosol] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Negative regulation of FGFR2 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
p-T250,T255,T385,S437-MKNK1 [cytosol] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Negative regulation of FGFR3 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
p-T250,T255,T385,S437-MKNK1 [cytosol] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
p-T250,T255,T385,S437-MKNK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BUB5 MKNK1
Gene Names
MKNK1, MNK1
Chain
chain:1-465
Reference Genes
BioGPS Gene:8569 MKNK1
COSMIC (genes):MKNK1 MKNK1
CTD Gene:8569 MKNK1
dbSNP Gene:8569 MKNK1
ENSEMBL:ENSG00000079277 MKNK1
ENSEMBL_homo_sapiens_GENE:ENSG00000079277.22 MKNK1
HGNC:7110 MKNK1
KEGG Gene (Homo sapiens):8569 MKNK1
Monarch:8569 MKNK1
NCBI Gene:8569 MKNK1
OMIM:606724 MKNK1
UCSC:Q9BUB5 MKNK1
Reference Transcript
RefSeq:XM_006711000.1 MKNK1
RefSeq:NM_001135553.2 MKNK1
RefSeq:XM_017002659.1 MKNK1
RefSeq:NM_003684.5 MKNK1
RefSeq:NM_198973.3 MKNK1
Other Identifiers
11718812_a_at
11748830_a_at
11756858_a_at
209467_PM_s_at
209467_s_at
2410726
2410728
2410730
2410732
2410734
2410736
2410738
2410740
2410742
2410746
2410748
2410750
2410760
2410768
2410772
2410774
2410782
2410796
2410806
2410812
2410828
2410830
2410832
2410838
2410840
3285393
3285394
35299_at
7915846
8569
AB000409_at
A_23_P200126
GE79378
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006417
GO:0006468
GO:0009931
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0023052
GO:0035556
GO:0036211
GO:0043226
GO:0046872
GO:0106310
GO:0140096
HMNXSV003028434
ILMN_1725738
ILMN_1750429
PH_hs_0022191
TC01005450.hg
g12803828_3p_a_at
Inferred To
phospho-MKNK1 [cytosol]
(Canis familiaris)
phospho-p-T250,T255,T385,S437-MKNK1 [cytosol]
(Bos taurus)
phospho-p-T250,T255,T385,S437-MKNK1 [cytosol]
(Drosophila melanogaster)
phospho-p-T250,T255,T385,S437-MKNK1 [cytosol]
(Mus musculus)
phospho-p-T250,T255,T385,S437-MKNK1 [cytosol]
(Rattus norvegicus)
phospho-p-T250,T255,T385,S437-MKNK1 [cytosol]
(Sus scrofa)
phospho-p-T250,T255,T385,S437-MKNK1 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 250
Coordinate
250
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 255
Coordinate
255
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 385
Coordinate
385
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 437
Coordinate
437
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_003675.2
,
XP_016858148.1
,
NP_001129025.1
,
NP_945324.1
,
XP_006711063.1
ZINC - World Drugs
MKNK1_HUMAN
Guide to Pharmacology - Targets
2104
OpenTargets
ENSG00000079277
ZINC - FDA approved
MKNK1_HUMAN
ZINC - Substances
MKNK1_HUMAN
ZINC target
Q9BUB5
ZINC - Biogenic
MKNK1_HUMAN
PRO
Q9BUB5
PDB
2Y9Q
,
2HW6
,
5WVD
ZINC - Investigational
MKNK1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000079277-MKNK1
GeneCards
Q9BUB5
Ensembl
ENST00000649800
,
ENSP00000497380
,
ENSP00000498143
,
ENST00000650026
,
ENSG00000079277
,
ENSP00000498083
,
ENST00000650508
Pharos - Targets
Q9BUB5
ZINC - Predictions - Purchasable
MKNK1_HUMAN
HMDB Protein
HMDBP01482
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.765
10
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.738
5
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.564
3
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
OPTN [Golgi membrane]
(R-HSA-2161111)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [cytosol]
(R-HSA-9687907)
0.556
3
UniProt:P54253 ATX1
0.556
6
UniProt:Q03060-25 CREM
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
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