Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi

Stable Identifier
R-HSA-947991
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The LMAN1(also known as ERGIC-53)/MCFD2 complex recognizes Man8 and Man9 N-glycans released by the Calnexin/Calreticulin cycle and mediate their transport to the Golgi (Nyefeler B et al, 2003; Zhang B et al, 2003). Man8 glycan transfer is shown here.

Literature References
PubMed ID Title Journal Year
12717434 Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

Zhang, B, Cunningham, MA, Nichols, WC, Bernat, JA, Seligsohn, U, Pipe, SW, McVey, JH, Schulte-Overberg, U, de Bosch, NB, Ruiz-Saez, A, White, GC, Tuddenham, EG, Kaufman, RJ, Ginsburg, D

Nat Genet 2003
12727195 The cargo receptor ERGIC-53 is a target of the unfolded protein response

Nyfeler, B, Nufer, O, Matsui, T, Mori, K, Hauri, HP

Biochem Biophys Res Commun 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
mannose binding activity of LMAN1:MCFD2 [ER to Golgi transport vesicle membrane]
Physical Entity
Activity
Authored
Reviewed
Created