Transport to the Golgi and subsequent modification

Stable Identifier
R-HSA-948021
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

At least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999). The other is mediated by LMAN1/MCFD2, mannose-binding lectins that recognize a glycan signal (Zhang B et al, 2003).

Literature References
PubMed ID Title Journal Year
3594573 The rate of bulk flow from the endoplasmic reticulum to the cell surface

Wieland, FT, Gleason, ML, Serafini, TA, Rothman, JE

Cell 1987
10412983 Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles

Martinez-Menárguez, JA, Geuze, HJ, Slot, JW, Klumperman, J

Cell 1999
12717434 Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

Zhang, B, Cunningham, MA, Nichols, WC, Bernat, JA, Seligsohn, U, Pipe, SW, McVey, JH, Schulte-Overberg, U, de Bosch, NB, Ruiz-Saez, A, White, GC, Tuddenham, EG, Kaufman, RJ, Ginsburg, D

Nat Genet 2003
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