Reactome | NELFB [cytosol]

NELFB [cytosol]

Stable Identifier

R-HSA-9603526

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NELF-B protein, Negative elongation factor B, NELF-B, Cofactor of BRCA1

Locations in the PathwayBrowser for interactor UniProt:O75525

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK3 (TRKC) (Homo sapiens)
      - NTRK3 as a dependence receptor (Homo sapiens)
        
        NTRK3(496-641) binds NELFB (Homo sapiens)
        
        NELFB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WX92 NELFB

Gene Names

NELFB, COBRA1, KIAA1182

Chain

chain:1-580

Reference Genes

BioGPS Gene:25920 NELFB

COSMIC (genes):NELFB NELFB

CTD Gene:25920 NELFB

dbSNP Gene:25920 NELFB

ENSEMBL:ENSG00000188986 NELFB

HGNC:24324 NELFB

KEGG Gene (Homo sapiens):25920 NELFB

Monarch:25920 NELFB

NCBI Gene:25920 NELFB

OMIM:611180 NELFB

UCSC:Q8WX92 NELFB

Reference Transcript

RefSeq:NM_015456.4 NELFB

Participant Of

input

NTRK3(496-641) binds NELFB

hasComponent

NTRK3(496-641):NELFB [cytosol]

Other forms of this molecule

NELFB [mitochondrial outer membrane]

NELFB [nucleoplasm]

Cross References

RefSeq

NP_056271.3

OpenTargets

ENSG00000188986

GeneCards

Q8WX92

HPA

ENSG00000188986-NELFB

PRO

Q8WX92

PDB

6GML

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.829	6
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.69	4
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.602	5
UniProt:Q09161 NCBP1	2	NCBP1 [cytosol] (R-HSA-162459) NCBP1 [nucleoplasm] (R-HSA-51469)	0.527	3
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.527	3
UniProt:P10620 MGST1	3	MGST1 [plasma membrane] (R-HSA-6806259) MGST1 [endoplasmic reticulum membrane] (R-HSA-158545) MGST1 [azurophil granule membrane] (R-HSA-6799226)	0.524	2
UniProt:O43583 DENR			0.524	2
UniProt:O75525 KHDRBS3	2	p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035) KHDRSB3 [nucleoplasm] (R-HSA-8849040)	0.524	2
UniProt:P38646 HSPA9	6	HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.524	2

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