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PEX19:PEX3 binds PEX16
Stable Identifier
R-HSA-9603797
Type
Reaction [binding]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
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Protein localization (Homo sapiens)
Class I peroxisomal membrane protein import (Homo sapiens)
PEX19:PEX3 binds PEX16 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The cytosolic PEX19:PEX3 complex binds PEX16 located in the peroxisomal membrane (inferred from human PEX19, human PEX16, and rat Pex3). Thus PEX16 serves as a docking factor. PEX3 is believed to be inserted in the peroxisomal membrane by this pathway and by direct co-translational insertion in the membrane of the endoplasmic reticulum that then buds to generate peroxisomes.
Participants
Input
PEX16 [peroxisomal membrane]
(Homo sapiens)
PEX19:PEX3 [cytosol]
(Homo sapiens)
Output
PEX16:PEX19:PEX3 [peroxisomal membrane]
(Homo sapiens)
Participates
as an event of
Class I peroxisomal membrane protein import (Homo sapiens)
Inferred From
PEX19:Pex3 binds PEX16 (Homo sapiens)
Authored
May, B (2018-03-19)
Reviewed
Fransen, M (2019-01-28)
Created
May, B (2018-03-24)
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