B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain

Stable Identifier
R-HSA-9603989
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The family of beta-1,3-galactosyltransferases (B3GALTs) transfer galactose (Gal) from UDP-alpha-D-galactose (UDP-Gal) to the β1,3 position of substrates with a terminal beta-N-acetylglucosamine (β-GlcNAc) residue. B3GALTs are involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Here, five members of this family (B3GALT1-5) can mediate the transfer of Gal to GlcNAc-β1,3-Gal-R, the precursor to blood group Type 1 oligosaccharide chains found in bodily secretions (Amado et al. 1998, Isshiki et al. 1999; review Hennet 2002).

Literature References
PubMed ID Title Journal Year
10212226 Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom

Isshiki, S, Togayachi, A, Kudo, T, Nishihara, S, Watanabe, M, Kubota, T, Kitajima, M, Shiraishi, N, Sasaki, K, Andoh, T, Narimatsu, H

J. Biol. Chem. 1999
12222957 The galactosyltransferase family

Hennet, T

Cell. Mol. Life Sci. 2002
9582303 A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family

Amado, M, Almeida, R, Carneiro, F, Levery, SB, Holmes, EH, Nomoto, M, Hollingsworth, MA, Hassan, H, Schwientek, T, Nielsen, PA, Bennett, EP, Clausen, H

J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity of B3GALTs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created