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JAG1 binds NOTCH4
Stable Identifier
R-HSA-9604247
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
JAG1 binds NOTCH4 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
JAG1 can activate NOTCH4 signaling, based on co-culture of JAG1-expressing and NOTCH4 expressing HUVEC cells (human umbilical vein endothelial cell line) (Shawber et al. 2007). JAG1 and NOTCH4 are upregulated in human ER+ breast cancers resistant to anti-estrogen therapy, which correlates with an increase in population of breast cancer stem cells (Simoes et al. 2015).
Participants
Input
JAG1 [plasma membrane]
(Homo sapiens)
NOTCH4 [plasma membrane]
(Homo sapiens)
Output
JAG1:NOTCH4 [plasma membrane]
(Homo sapiens)
Entity On Other Cell
JAG1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Event Information
Go Biological Process
positive regulation of Notch signaling pathway (0045747)
Inferred From
Jag1 binds Notch4 (Mus musculus)
Authored
Jassal, B (2004-12-15)
Orlic-Milacic, M (2018-04-05)
Reviewed
Joutel, A (2004-12-15)
Haw, R (2018-05-01)
Created
Orlic-Milacic, M (2018-04-02)
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