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ADAM10 cleaves NOTCH4
Stable Identifier
R-HSA-9604264
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
ADAM10 cleaves NOTCH4 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on sequence similarity with other NOTCH family members and the requirement for knockout of both Notch1 and Notch4 in endothelial cells to recapitulate vasculature defects seen upon endothelial cell-specific Adam10 knockout, it is plausible that ADAM10 cleaves ligand-activated NOTCH4, releasing the membrane-bound NEXT4 fragment (Alabi et al. 2016).
Participants
Input
DLL4:NOTCH4,JAG1:NOTCH4 [plasma membrane]
(Homo sapiens)
Output
NEXT4 [plasma membrane]
(Homo sapiens)
Participates
as an event of
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Event Information
Go Biological Process
Notch receptor processing, ligand-dependent (0035333)
Catalyst Activity
metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]
Physical Entity
ADAM10:Zn2+ [plasma membrane]
(Homo sapiens)
Activity
metallopeptidase activity (GO:0008237)
Inferred From
Adam10 cleaves Notch4 (Mus musculus)
Authored
Jassal, B (2004-12-15)
Orlic-Milacic, M (2018-04-05)
Reviewed
Joutel, A (2004-12-15)
Haw, R (2018-05-01)
Created
Orlic-Milacic, M (2018-04-02)
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