ADAM10 cleaves NOTCH4

Stable Identifier
R-HSA-9604264
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Based on sequence similarity with other NOTCH family members and the requirement for knockout of both Notch1 and Notch4 in endothelial cells to recapitulate vasculature defects seen upon endothelial cell-specific Adam10 knockout, it is plausible that ADAM10 cleaves ligand-activated NOTCH4, releasing the membrane-bound NEXT4 fragment (Alabi et al. 2016).

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Event Information
Catalyst Activity
Catalyst Activity
Title
metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]
Physical Entity
Activity
Inferred From
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Created