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Gamma-secretase cleaves NOTCH4
Stable Identifier
R-HSA-9604294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves NOTCH4 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD4 into the cytosol (Saxena et al. 2001, Das et al. 2004).
Participants
Input
NEXT4 [plasma membrane]
(Homo sapiens)
Output
NICD4 [cytosol]
(Homo sapiens)
NOTCH4(1432-1466) [plasma membrane]
(Homo sapiens)
Participates
as an event of
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Event Information
Go Biological Process
Notch receptor processing, ligand-dependent (0035333)
Catalyst Activity
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
gamma-secretase complex [plasma membrane]
(Homo sapiens)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Inferred From
Gamma-secretase cleaves Notch4 (Homo sapiens)
Authored
Jassal, B (2004-12-15)
Orlic-Milacic, M (2018-04-05)
Reviewed
Joutel, A (2004-12-15)
Haw, R (2018-05-01)
Created
Orlic-Milacic, M (2018-04-02)
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