NICD4 traffics to the nucleus

Stable Identifier
R-HSA-9604308
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The cytosolic NICD4 translocates to the nucleus. Trafficking of NICD4 to the nucleus is negatively regulated by binding of NICD4 to 14-3-3-zeta (YWHAZ), which happens upon NICD4 phosphorylation by activated AKT1 (Ramakrishnan et al. 2015).

Literature References
PubMed ID Title Journal Year
25740432 AKT and 14-3-3 regulate Notch4 nuclear localization

Ramakrishnan, G, Davaakhuu, G, Chung, WC, Zhu, H, Rana, A, Filipovic, A, Green, AR, Atfi, A, Pannuti, A, Miele, L, Tzivion, G

Sci Rep 2015
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This event is regulated
Orthologous Events
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