HES5 gene expression is stimulated by NOTCH4

Stable Identifier
R-HSA-9604446
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HES5 gene expression is stimulated by NOTCH4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The NOTCH4 co-activator complex, composed of NICD4 (NOTCH4 intracellular domain), RBPJ (CSL) and one of mastermind proteins, MAML1, MAML2 or MAML3, stimulates transcription from the HES5 gene promoter. The highest level of transcriptional activation of HES5 by NOTCH4 is seen when MAML2 is overexpressed, compared to the other two MAML proteins (Lin et al. 2002).
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of transcription, DNA-templated (0045893)
This event is regulated
Positively by
Regulator
NOTCH4 coactivator complex [nucleoplasm] (Homo sapiens)
Inferred From
HES5 gene transcription is stimulated by Notch4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-03)
Cite Us!