SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters

Stable Identifier
R-HSA-9604829
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in mice, SIRT6 deacetylates H3 histones on lysine residue 10 (removing the H3K9Ac epigenetic mark) at promoters of NOTCH1 and NOTCH4 genes (Liu et al. 2017).

Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
NAD-dependent histone deacetylase activity (H3-K9 specific) of SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
Cite Us!