Reactome | FUT3 transfers Fuc to Type 1 DSGG to form dsLeA

FUT3 transfers Fuc to Type 1 DSGG to form dsLeA

Stable Identifier

R-HSA-9605644

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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FUT3 transfers Fuc to Type 1 DSGG to form dsLeA

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The FUT3 gene (originally named the Le gene) expresses galactoside 3(4)-L-fucosyltransferase present on the Golgi membrane. FUT3 catalyses the α1,4 and α1,3 addition of fucose to Type 1 and Type 2 oligosaccharide chains respectively, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the subterminal N-acetylglucosaminyl (GlcNAc) residue of Type 1 disialylgalactosylgloboside (Type 1 DSGG) in an α1,4 linkage forms the disialyl-Lewis A antigen (dsLeA).

Literature References

PubMed ID	Title	Journal	Year
1977660	A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase Larsen, RD, Lowe, JB, Kukowska-Latallo, JF, Nair, RP	Genes Dev.	1990