Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

Stable Identifier
R-HSA-9606151
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated BLNK (also called BASH or SLP-65) at the plasma membrane recruits BTK, PLC gamma, VAV, GRB2, and NCK (Fu and Chan 1997, Fu et al. 1998, Wienands et al. 1998, Su et al. 1999, Baba et al. 2001, Chiu et al. 2002). The SH2 domain of BTK binds phosphorylated BLNK (Hashimoto et al. 1999, Su et al. 1999, Baba et al. 2001). BLNK is constitutively bound to CIN85 and phosphorylated BLNK is bound to a large complex containing CIN85, SOS1, GRB2, phosphorylated SYK, and the B cell receptor.

Literature References
PubMed ID Title Journal Year
10556826 Interaction of SLP adaptors with the SH2 domain of Tec family kinases

Su, YW, Zhang, Y, Schweikert, J, Koretzky, GA, Reth, M, Wienands, J

Eur. J. Immunol. 1999
9705962 SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

Wienands, J, Schweikert, J, Wollscheid, B, Jumaa, H, Nielsen, PJ, Reth, M

J Exp Med 1998
11226282 BLNK mediates Syk-dependent Btk activation

Baba, Y, Hashimoto, S, Matsushita, M, Watanabe, D, Kishimoto, T, Kurosaki, T, Tsukada, S

Proc Natl Acad Sci U S A 2001
10498607 Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling

Hashimoto, S, Iwamatsu, A, Ishiai, M, Okawa, K, Yamadori, T, Matsushita, M, Baba, Y, Kishimoto, T, Kurosaki, T, Tsukada, S

Blood 1999
12456653 BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

Chiu, CW, Dalton, M, Ishiai, M, Kurosaki, T, Chan, AC

EMBO J 2002
9697839 BLNK: a central linker protein in B cell activation

Fu, C, Turck, CW, Kurosaki, T, Chan, AC

Immunity 1998
21822214 The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85

Oellerich, T, Bremes, V, Neumann, K, Bohnenberger, H, Dittmann, K, Hsiao, HH, Engelke, M, Schnyder, T, Batista, FD, Urlaub, H, Wienands, J

EMBO J 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created