Phosphorylated BTK phosphorylates PLCG2

Stable Identifier
R-HSA-9606162
Type
Reaction [transition]
Species
Homo sapiens
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Activated BTK (BTK phosphorylated on tyrosine-551 and tyrosine-223) bound to phosphorylated BLNK phosphorylates phospholipase gamma-2 (PKCG2) on tyrosines 753, 759, and 1217 (Rodriguez et al. 2001 and inferred from the rat homolog) thereby activating PLCG2 to hydrolyze phosphatidylinositol 4,5-bisphosphate, yielding the second messengers diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (Carter et al. 1991, Roifman and Wang 1992, Kim et al. 2004, Sekiya et al. 2004). PLCG2 also binds phosphoinositol 3,4,5-trisphosphate (PIP3) produced by PI3K at the plasma membrane.

Literature References
PubMed ID Title Journal Year
1550550 Phospholipase C-gamma 1 and phospholipase C-gamma 2 are substrates of the B cell antigen receptor associated protein tyrosine kinase

Roifman, CM, Wang, G

Biochem Biophys Res Commun 1992
11606584 Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling

Rodriguez, R, Matsuda, M, Perisic, O, Bravo, J, Paul, A, Jones, NP, Light, Y, Swann, K, Williams, RL, Katan, M

J Biol Chem 2001
15509800 Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2

Kim, YJ, Sekiya, F, Poulin, B, Bae, YS, Rhee, SG

Mol Cell Biol 2004
15161916 Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation

Sekiya, F, Poulin, B, Kim, YJ, Rhee, SG

J Biol Chem 2004
2011584 Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes

Carter, RH, Park, DJ, Rhee, SG, Fearon, DT

Proc Natl Acad Sci U S A 1991
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Catalyst Activity
Title
protein tyrosine kinase activity of Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane]
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