p-SYK and LYN phosphorylate BTK

Stable Identifier
R-HSA-9606163
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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LYN and activated (phosphorylated) SYK phosphorylate BTK (Baba et al. 2001, Lin et al. 2009, also inferred from chicken homologs and mouse homologs) after BTK is recruited to the plasma membrane by phosphorylated BLNK (Baba et al. 2001) and phosphoinositol 3,4,5-trisphosphate (PIP3) (Salim et al. 1996). Phosphorylation of tyrosine-551 occurs within 30 seconds of B cell receptor activation and returns to low phosphorylation after 30 minutes (Nisitani et al. 1999).

Literature References
PubMed ID Title Journal Year
19206206 Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity

Lin, L, Czerwinski, R, Kelleher, K, Siegel, MM, Wu, P, Kriz, R, Aulabaugh, A, Stahl, M

Biochemistry 2009
10051622 In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

Nisitani, S, Kato, RM, Rawlings, DJ, Witte, ON, Wahl, MI

Proc. Natl. Acad. Sci. U.S.A. 1999
8947047 Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

Salim, K, Bottomley, MJ, Querfurth, E, Zvelebil, MJ, Gout, I, Scaife, R, Margolis, RL, Gigg, R, Smith, CI, Driscoll, PC, Waterfield, MD, Panayotou, G

EMBO J. 1996
11226282 BLNK mediates Syk-dependent Btk activation

Baba, Y, Hashimoto, S, Matsushita, M, Watanabe, D, Kishimoto, T, Kurosaki, T, Tsukada, S

Proc Natl Acad Sci U S A 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LYN, p-SYK [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created