Reactome | p-Y551-BTK [plasma membrane]

p-Y551-BTK [plasma membrane]

Stable Identifier

R-HSA-9606165

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

BTK phosphorylated at Tyr-223 and Tyr-551, Tyrosine-protein kinase BTK, BTK_HUMAN, BTK

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
17264076	Activation mechanism and steady state kinetics of Bruton's tyrosine kinase Dinh, M, Grunberger, D, Ho, H, Tsing, SY, Shaw, D, Lee, S, Barnett, J, Hill, RJ, Swinney, DC, Bradshaw, JM	J Biol Chem	2007

External Reference Information

External Reference

UniProt:Q06187 BTK

Gene Names

BTK, AGMX1, ATK, BPK

Chain

initiator methionine:1, chain:2-659

Reference Genes

BioGPS Gene:695 BTK

COSMIC (genes):BTK BTK

CTD Gene:695 BTK

dbSNP Gene:695 BTK

ENSEMBL:ENSG00000010671 BTK

HGNC:1133 BTK

KEGG Gene (Homo sapiens):695 BTK

Monarch:695 BTK

NCBI Gene:695 BTK

OMIM:300300 BTK

UCSC:Q06187 BTK

Reference Transcript

Other Identifiers

11730847_a_at

11756709_x_at

17112735

205504_at

38213_at

4015705

4015710

4015711

4015713

4015714

4015716

4015718

4015720

4015721

4015724

4015729

4015730

4015731

4015732

4015733

4015734

4015735

4015736

4015738

4015741

4015743

4015745

4015746

4015751

4015752

4015755

8174051

A_23_P137139

A_33_P3277514

GE61511

GO:0000166

GO:0001805

GO:0001812

GO:0001818

GO:0002250

GO:0002344

GO:0002376

GO:0002553

GO:0002721

GO:0002755

GO:0002902

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005547

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006810

GO:0006915

GO:0006950

GO:0007165

GO:0007186

GO:0007249

GO:0007267

GO:0007498

GO:0008150

GO:0008219

GO:0008283

GO:0008289

GO:0009058

GO:0010033

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019722

GO:0021700

GO:0030154

GO:0030889

GO:0031410

GO:0034614

GO:0034641

GO:0035556

GO:0038095

GO:0042113

GO:0042629

GO:0042802

GO:0043167

GO:0043226

GO:0045087

GO:0045121

GO:0045579

GO:0046777

GO:0046872

GO:0048469

GO:0048471

GO:0048856

GO:0050853

GO:0051092

GO:0071226

GO:0097190

GO:0098761

ILMN_1662026

PH_hs_0009711

TC0X001218.hg

TC0X002155.hg

U78027_rna4_at

g4557376_3p_at

Participant Of

hasComponent

p-Y551-BTK:PIP3 [plasma membrane]

Other forms of this molecule

Active BTK [cytosol]

p-Y223,Y551-BTK [cytosol]

p-Y551-BTK [cytosol]

p-Y223,Y551-BTK [plasma membrane]

BTK [cytosol]

Modified Residues

Name

O4'-phospho-L-tyrosine at 551

Coordinate

551

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001274273.1, NP_001274274.1, NP_000052.1

ZINC - World Drugs

BTK_HUMAN

OpenTargets

ENSG00000010671

ZINC - FDA approved

BTK_HUMAN

ZINC - Substances

BTK_HUMAN

ZINC - Biogenic

BTK_HUMAN

ZINC target

Q06187

PRO

Q06187

PDB

6BLN, 5BPY, 5P9G, 4ZLZ, 4OTF, 5T18, 3OCS, 5P9F, 1K2P, 6HRP, 6BIK, 5BQ0, 4YHF, 5ZZ4, 3OCT, 4OT5, 1B55, 5XYZ, 4RFZ, 5FBN, 1AWX, 6HRT, 5FBO, 6DI0, 4OTQ, 3PJ1, 5P9I, 5P9J, 6NZM, 2GE9, 6NFH, 1AWW, 6NFI, 5VFI, 6AUB, 6DI1, 4OTR, 3K54, 4RX5, 5P9K, 6DI5, 5JRS, 1BTK, 6BKE, 5P9M, 6O8I, 4NWM, 4RFY, 6E4F, 2Z0P, 4RG0, 5U9D, 6BKH, 1BWN, 5VGO, 5P9H, 3PIX, 6AUA, 5KUP, 6N9P, 5J87, 6BKW, 3PIY, 6J6M, 4Z3V, 3GEN, 6DI3, 6OMU, 6S90, 3PIZ, 3P08, 6EP9, 3PJ2, 4OT6, 5P9L, 3PJ3, 4ZLY, 6DI9, 1QLY

ZINC - Investigational

BTK_HUMAN

HPA

ENSG00000010671-BTK

GeneCards

Q06187

Ensembl

ENSP00000308176, ENST00000621635, ENST00000308731, ENSP00000483570, ENSG00000010671

Orphanet

15383

ZINC - Predictions - Purchasable

BTK_HUMAN

HMDB Protein

HMDBP01420

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78347 GTF2I			0.724	6
UniProt:Q8WV28 BLNK	2	p-5Y-BLNK [plasma membrane] (R-HSA-983579) BLNK [cytosol] (R-HSA-912750)	0.667	4
IntAct:EBI-1521221			0.633	4
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323) p-Y551-BTK [cytosol] (R-HSA-2685603) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807) BTK [cytosol] (R-HSA-197948)	0.623	3
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.558	2
UniProt:Q99856 ARID3A	1	ARID3A [nucleoplasm] (R-HSA-3782552)	0.558	3
UniProt:P21145 MAL			0.556	5
UniProt:P50222 MEOX2			0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:O60239 3BP5			0.524	4
UniProt:Q04759 PRKCQ	9	PRKCQ(1-354) [cytosol] (R-HSA-212526) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ [cytosol] (R-HSA-58216) p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [plasma membrane] (R-HSA-202346) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606)	0.524	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2
ChEBI:39112 BOSUTINIB			0.499	2
ChEBI:49375 DASATINIB			0.499	2
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.488	2
UniProt:Q9P2D0 IBTK			0.463	2