p-Y551-BTK [plasma membrane]

Stable Identifier
R-HSA-9606165
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BTK phosphorylated at Tyr-223 and Tyr-551, Tyrosine-protein kinase BTK, BTK_HUMAN, BTK
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
17264076 Activation mechanism and steady state kinetics of Bruton's tyrosine kinase

Shaw, D, Lee, S, Grunberger, D, Hill, RJ, Swinney, DC, Dinh, M, Barnett, J, Ho, H, Bradshaw, JM, Tsing, SY

J Biol Chem 2007
External Reference Information
External Reference
UniProt:Q06187 BTK
Gene Names
BTK, AGMX1, ATK, BPK
Chain
initiator methionine:1, chain:2-659
Reference Genes
BioGPS Gene:695 BTK
COSMIC (genes):BTK BTK
CTD Gene:695 BTK
dbSNP Gene:695 BTK
ENSEMBL:ENSG00000010671.17 BTK
HGNC:1133 BTK
KEGG Gene (Homo sapiens):695 BTK
Monarch:695 BTK
NCBI Gene:695 BTK
OMIM:300300 BTK
UCSC:Q06187 BTK
Reference Transcript
Other Identifiers
11730847_a_at
11756709_x_at
17112735
205504_PM_at
205504_at
38213_at
4015705
4015710
4015711
4015713
4015714
4015716
4015718
4015720
4015721
4015724
4015729
4015730
4015731
4015732
4015733
4015734
4015735
4015736
4015738
4015741
4015743
4015745
4015746
4015751
4015752
4015755
695
8174051
A_33_P3277514
GO:0000166
GO:0001780
GO:0001805
GO:0001812
GO:0001818
GO:0002250
GO:0002344
GO:0002376
GO:0002553
GO:0002639
GO:0002721
GO:0002755
GO:0002902
GO:0003674
GO:0004672
GO:0004712
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005547
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006954
GO:0007249
GO:0007498
GO:0008150
GO:0008289
GO:0010033
GO:0012501
GO:0016004
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019722
GO:0019899
GO:0023052
GO:0030154
GO:0030163
GO:0030167
GO:0030234
GO:0030889
GO:0030890
GO:0031410
GO:0032496
GO:0032693
GO:0032755
GO:0032760
GO:0034614
GO:0035556
GO:0036211
GO:0038083
GO:0038095
GO:0042113
GO:0042802
GO:0043167
GO:0043226
GO:0043274
GO:0045087
GO:0045121
GO:0045579
GO:0046777
GO:0046872
GO:0048469
GO:0048471
GO:0048856
GO:0050729
GO:0050766
GO:0050790
GO:0050853
GO:0050869
GO:0051092
GO:0061516
GO:0070664
GO:0071226
GO:0097190
GO:0098542
GO:0098761
GO:0150153
GO:1901135
GO:1901647
GO:1990959
HMNXSV003005100
ILMN_1662026
PH_hs_0009711
TC0X001218.hg
TC0X002155.hg
U78027_rna4_at
g4557376_3p_at
Participates
as a component of
Other forms of this molecule
Active BTK [cytosol]
p-Y223,Y551-BTK [cytosol]
p-Y551-BTK [cytosol]
BTK [cytosol]
p-Y223,Y551-BTK [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 551
Coordinate
551
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
HPA
GeneCards
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (17)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P78347 GTF2I      0.724 6
 UniProt:Q8WV28 BLNK  2 0.667 4
 IntAct:EBI-1521221      0.633 4
 UniProt:Q06187 BTK  6 0.623 3
 UniProt:Q99856 ARID3A  1 0.558 3
 UniProt:Q13444 ADAM15  1 0.558 2
 UniProt:P21145 MAL      0.556 5
 UniProt:P50222 MEOX2      0.556 3
 UniProt:P62993 GRB2  1 0.547 2
 UniProt:Q6NXT1 ANR54      0.527 2
 UniProt:O60239 3BP5      0.524 4
 UniProt:P08238 HSP90AB1  6 0.524 2
 UniProt:Q04759 PRKCQ  9 0.524 2
 ChEBI:39112 BOSUTINIB      0.499 2
 ChEBI:49375 DASATINIB      0.499 2
 UniProt:Q92569 PIK3R3  2 0.488 2
 UniProt:Q9P2D0 IBTK      0.463 2
Cite Us!