p-CD19:VAV binds PI3K and GRB2

Stable Identifier
R-HSA-9606887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated CD19 binds PI3K (Roifman and Ke 1993, Chalupny et al. 1993, Uckun et al. 1993, Weng et al. 1994, Brooks et al. 2000, Brooks et al. 2004) and can bind PLC-gamma2 (PLCG2), which competes with VAV1 for the binding to phosphotyrosine-391 on CD19 (Brooks et al. 2000, Brooks et al. 2004). GRB2 appears to bind phosphotyrosine-330 on CD19 (Brooks et al. 2004).

Literature References
PubMed ID Title Journal Year
7691807 Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny

Uckun, FM, Burkhardt, AL, Jarvis, L, Jun, X, Stealey, B, Dibirdik, I, Myers, DE, Tuel-Ahlgren, L, Bolen, JB

J Biol Chem 1993
7528218 Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors

Weng, WK, Jarvis, L, LeBien, TW

J Biol Chem 1994
7687539 Tyrosine phosphorylation of CD19 in pre-B and mature B cells

Chalupny, NJ, Kanner, SB, Schieven, GL, Wee, SF, Gilliland, LK, Aruffo, A, Ledbetter, JA

EMBO J 1993
7687428 CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells

Roifman, CM, Ke, S

Biochem Biophys Res Commun 1993
10706702 Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines

Brooks, SR, Li, X, Volanakis, EJ, Carter, RH

J Immunol 2000
15187135 Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric

Brooks, SR, Kirkham, PM, Freeberg, L, Carter, RH

J Immunol 2004
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