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p-DAPP1 (p-BAM32) binds PLCG2
Stable Identifier
R-HSA-9606894
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)
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Phosphorylated DAPP1 (BAM32) bound to phosphoinositol 3,4,5-trisphosphate (PIP3) at the plasma membrane binds phospholipase gamma-2 (PLCG2) (Marshall et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
10770799
A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase
Thomas, S
,
Yun, TJ
,
Lerner, CG
,
Clark, EA
,
Marshall, AJ
,
Disteche, CM
,
Niiro, H
J Exp Med
2000
Participants
Input
p-Y139-DAPP1:PIP3 [plasma membrane]
(Homo sapiens)
PLCG2 [cytosol]
(Homo sapiens)
Output
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
Orthologous Events
p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)
p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)
p-DAPP1 (p-BAM32) binds PLCG2 (Dictyostelium discoideum)
p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)
p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)
p-DAPP1 (p-BAM32) binds PLCG2 (Plasmodium falciparum)
p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)
p-DAPP1 (p-BAM32) binds PLCG2 (Saccharomyces cerevisiae)
p-DAPP1 (p-BAM32) binds PLCG2 (Schizosaccharomyces pombe)
p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)
p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)
Authored
May, B (2018-04-23)
Reviewed
Wienands, J (2018-07-18)
Created
May, B (2018-04-26)
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