SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)

Stable Identifier
R-HSA-9607304
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Son of sevenless homolog 1 (SOS1) is the guanine nucleotide exchange factor (GEF) for rat sarcoma (RAS) protein. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D

Science 1993
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of Active FLT3:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created