The C-terminal domains of a SGTA dimer bind the C-terminal hydrophobic transmembrane domain (TMD) of a tail-anchored (TA) protein shortly after it emerges from the ribosome (Liou and Wang 2005, Leznicki et al. 2011, Wunderley et al. 2014, Shao et al. 2017). Binding of SGTA shields the TMD of the TA protein and stabilizes the TA protein by preventing it from being targeted for degradation (Leznicki and High 2012).