SGTA binds Tail-anchored protein

Stable Identifier
Reaction [binding]
Homo sapiens
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The C-terminal domains of a SGTA dimer bind the C-terminal hydrophobic transmembrane domain (TMD) of a tail-anchored (TA) protein shortly after it emerges from the ribosome (Liou and Wang 2005, Leznicki et al. 2011, Wunderley et al. 2014, Shao et al. 2017). Binding of SGTA shields the TMD of the TA protein and stabilizes the TA protein by preventing it from being targeted for degradation (Leznicki and High 2012).

Literature References
PubMed ID Title Journal Year
23129660 SGTA antagonizes BAG6-mediated protein triage

High, S, Leznicki, P

Proc. Natl. Acad. Sci. U.S.A. 2012
25179605 SGTA regulates the cytosolic quality control of hydrophobic substrates

High, S, Payapilly, A, Leznicki, P, Wunderley, L

J. Cell. Sci. 2014
28104892 Mechanistic basis for a molecular triage reaction

Hegde, RS, Shao, S, Kivlen, MH, Rodrigo-Brenni, MC

Science 2017
15708368 Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions

Liou, ST, Wang, C

Arch. Biochem. Biophys. 2005
21466504 A biochemical analysis of the constraints of tail-anchored protein biogenesis

High, S, Warwicker, J, Leznicki, P

Biochem. J. 2011
Orthologous Events
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