Reactome | SGTA binds Tail-anchored protein

SGTA binds Tail-anchored protein

Stable Identifier

R-HSA-9609921

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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The C-terminal domains of a SGTA dimer bind the C-terminal hydrophobic transmembrane domain (TMD) of a tail-anchored (TA) protein shortly after it emerges from the ribosome (Liou and Wang 2005, Leznicki et al. 2011, Wunderley et al. 2014, Shao et al. 2017). Binding of SGTA shields the TMD of the TA protein and stabilizes the TA protein by preventing it from being targeted for degradation (Leznicki and High 2012).

Literature References

PubMed ID	Title	Journal	Year
25179605	SGTA regulates the cytosolic quality control of hydrophobic substrates Wunderley, L, Leznicki, P, Payapilly, A, High, S	J. Cell. Sci.	2014
23129660	SGTA antagonizes BAG6-mediated protein triage Leznicki, P, High, S	Proc. Natl. Acad. Sci. U.S.A.	2012
28104892	Mechanistic basis for a molecular triage reaction Shao, S, Rodrigo-Brenni, MC, Kivlen, MH, Hegde, RS	Science	2017
15708368	Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions Liou, ST, Wang, C	Arch. Biochem. Biophys.	2005
21466504	A biochemical analysis of the constraints of tail-anchored protein biogenesis Leznicki, P, Warwicker, J, High, S	Biochem. J.	2011