SGTA binds Tail-anchored protein

Stable Identifier
R-HSA-9609921
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SGTA binds Tail-anchored protein
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The C-terminal domains of a SGTA dimer bind the C-terminal hydrophobic transmembrane domain (TMD) of a tail-anchored (TA) protein shortly after it emerges from the ribosome (Liou and Wang 2005, Leznicki et al. 2011, Wunderley et al. 2014, Shao et al. 2017). Binding of SGTA shields the TMD of the TA protein and stabilizes the TA protein by preventing it from being targeted for degradation (Leznicki and High 2012).
Literature References
PubMed ID Title Journal Year
23129660 SGTA antagonizes BAG6-mediated protein triage

Leznicki, P, High, S

Proc. Natl. Acad. Sci. U.S.A. 2012
25179605 SGTA regulates the cytosolic quality control of hydrophobic substrates

Wunderley, L, Leznicki, P, Payapilly, A, High, S

J. Cell. Sci. 2014
28104892 Mechanistic basis for a molecular triage reaction

Shao, S, Rodrigo-Brenni, MC, Kivlen, MH, Hegde, RS

Science 2017
15708368 Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions

Liou, ST, Wang, C

Arch. Biochem. Biophys. 2005
21466504 A biochemical analysis of the constraints of tail-anchored protein biogenesis

Leznicki, P, Warwicker, J, High, S

Biochem. J. 2011
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Orthologous Events
SGTA binds Tail-anchored protein (Bos taurus)
SGTA binds Tail-anchored protein (Caenorhabditis elegans)
SGTA binds Tail-anchored protein (Canis familiaris)
SGTA binds Tail-anchored protein (Danio rerio)
SGTA binds Tail-anchored protein (Dictyostelium discoideum)
SGTA binds Tail-anchored protein (Drosophila melanogaster)
SGTA binds Tail-anchored protein (Gallus gallus)
SGTA binds Tail-anchored protein (Mus musculus)
SGTA binds Tail-anchored protein (Plasmodium falciparum)
SGTA binds Tail-anchored protein (Rattus norvegicus)
SGTA binds Tail-anchored protein (Saccharomyces cerevisiae)
SGTA binds Tail-anchored protein (Schizosaccharomyces pombe)
SGTA binds Tail-anchored protein (Sus scrofa)
SGTA binds Tail-anchored protein (Xenopus tropicalis)
Authored
May, B  (2018-06-03)
Reviewed
DeLaurentiis, E  (2018-11-07)
Farkas, Á  (2018-11-07)
Schwappach, B  (2018-11-07)
Created
May, B  (2018-06-03)
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