SGTA binds Tail-anchored protein

Stable Identifier
R-HSA-9609921
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The C-terminal domains of a SGTA dimer bind the C-terminal hydrophobic transmembrane domain (TMD) of a tail-anchored (TA) protein shortly after it emerges from the ribosome (Liou and Wang 2005, Leznicki et al. 2011, Wunderley et al. 2014, Shao et al. 2017). Binding of SGTA shields the TMD of the TA protein and stabilizes the TA protein by preventing it from being targeted for degradation (Leznicki and High 2012).

Literature References
PubMed ID Title Journal Year
25179605 SGTA regulates the cytosolic quality control of hydrophobic substrates

Wunderley, L, Leznicki, P, Payapilly, A, High, S

J. Cell. Sci. 2014
23129660 SGTA antagonizes BAG6-mediated protein triage

Leznicki, P, High, S

Proc. Natl. Acad. Sci. U.S.A. 2012
28104892 Mechanistic basis for a molecular triage reaction

Shao, S, Rodrigo-Brenni, MC, Kivlen, MH, Hegde, RS

Science 2017
15708368 Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions

Liou, ST, Wang, C

Arch. Biochem. Biophys. 2005
21466504 A biochemical analysis of the constraints of tail-anchored protein biogenesis

Leznicki, P, Warwicker, J, High, S

Biochem. J. 2011
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