Activated BRAF recruits MAP2Ks and MAPKs to the endosome

Stable Identifier
R-HSA-9610152
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
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Activated BRAF recruits MAP2Ks and MAPKs to the endosome
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Downstream of NGF stimulation and RAP1 activation, BRAF recruits MAP2Ks and MAPKs to the endosome to promote sustained RAF/MAPK signaling (York et al, 1998; reviewed in Reichardt, 2006; Barford et al, 2017).
Literature References
PubMed ID Title Journal Year
16939974 Neurotrophin-regulated signalling pathways

Reichardt, LF

Philos Trans R Soc Lond B Biol Sci 2006
27503831 The neurotrophin receptor signaling endosome: Where trafficking meets signaling

Barford, K, Deppmann, C, Winckler, B

Dev Neurobiol 2017
9560161 Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

Stork, PJ, McCleskey, EW, Dillon, T, Eckert, SP, Yao, H, York, RD, Ellig, CL

Nature 1998
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Authored
Rothfels, K  (2018-06-05)
Reviewed
D'Eustachio, P  (2019-08-12)
Created
Rothfels, K  (2018-06-05)
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