Reactome | GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane

GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane

Stable Identifier

R-HSA-9610750

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, plasma membrane

ReviewStatus

5/5

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GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane

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NMDA receptors composed of GluN1 (GRIN1) and various combinations of GluN2 (GRIN2) subunits (GluN2A, GluN2B, GluN2C and GluN2D) are all delivered to the plasma membrane where they are anchored to postsynaptic density regions via the interaction with the PSD-95 family of proteins (DLG1, DLG2, DLG3 and DLG3) (Cui et al. 2007). Details of trafficking from the endoplasmic reticulum to the plasma membrane for the majority of GluN1:GluN2 di-heteromers and tri-heteromers, except for GluN1:GluN2B NMDA receptors, are not known.

Literature References

PubMed ID	Title	Journal	Year
17855605	PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors Garman, D, Cui, H, Tymianski, M, Phan, T, Sun, HS, Lu, PS, Belmares, MP, Salter, MW, Tasker, RA, Hayashi, A, Wang, YT, Cobey, C, Schweizer, J, Rabinowitz, J	J. Neurosci.	2007