Reactome | YRDC synthesizes threonylcarbamoyladenylate

YRDC synthesizes threonylcarbamoyladenylate

Stable Identifier

R-HSA-9611218

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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YRDC synthesizes threonylcarbamoyladenylate

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In vitro, YRDC and OSGEPL1 catalyze the threonylcarbamoylation of adenosine-37 of 5 mitochondrial tRNAs: tRNA(Asn), tRNA(Ile), tRNA(Lys), tRNA(Ser)(AGY), tRNA(Thr) (Lin et al. 2018, reviewed in Su et al. 2022). YRDC and OSGEPL1 are also required for the reaction in vivo. Based on bacterial and yeast homologs, YRDC is believed to catalyze the formation of threonylcarbamoyladenylate from bicarbonate, L-threonine, and ATP. Threonylcarbamoyladenylate and tRNA are the substrates for OSGEPL1.

Literature References

PubMed ID	Title	Journal	Year
29760464	CO₂-sensitive tRNA modification associated with human mitochondrial disease Lin, H, Miyauchi, K, Harada, T, Okita, R, Takeshita, E, Komaki, H, Fujioka, K, Yagasaki, H, Goto, YI, Yanaka, K, Nakagawa, S, Sakaguchi, Y, Suzuki, T	Nat Commun	2018