ADRB3 bind ADR,NAd

Stable Identifier
R-HSA-9611852
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Beta-3 adrenoceptors bind catecholamines
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

β-adrenergic receptors couple with G protein alpha-s subtype (Wenzel-Seifert K et al, 2002), increasing cAMP activity resulting in heart muscle contraction, smooth muscle relaxation and glycogenolysis. There are three β subtypes in humans; β1 found mainly in the heart and kidneys (Frielle et al. 1987), β2 found mainly in the lungs, vascular smooth muscle and skeletal muscle (Kobilka et al. 1987) and β3 found mainly in fat cells (Emorine et al. 1989). The catecholamines adrenaline (ADR) and noradrenaline (NaAd) are natural endogenous ligands that bind to β-adrenergic receptors and cause general physiological changes (increases in heart rate, blood pressure and glucose levels) that prepare the body for physical activity ('fight-or-flight response') (Tank & Lee Wong 2015).

Literature References
PubMed ID Title Journal Year
12106601 Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants

Wenzel-Seifert, K, Liu, HY, Seifert, R

Biochem Pharmacol 2002
2570461 Molecular characterization of the human beta 3-adrenergic receptor

Emorine, LJ, Marullo, S, Briend-Sutren, MM, Patey, G, Tate, K, Delavier-Klutchko, C, Strosberg, AD

Science 1989
2825170 Cloning of the cDNA for the human beta 1-adrenergic receptor

Frielle, T, Collins, S, Daniel, KW, Caron, MG, Lefkowitz, RJ, Kobilka, BK

Proc Natl Acad Sci U S A 1987
3025863 cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor

Kobilka, BK, Dixon, RA, Frielle, T, Dohlman, HG, Bolanowski, MA, Sigal, IS, Yang-Feng, TL, Francke, U, Caron, MG, Lefkowitz, RJ

Proc Natl Acad Sci U S A 1987
Participants
Participant Of
hasEvent
This event is regulated
Orthologous Events
Authored
Reviewed
Created