Reactome | ERBB4s80 binds to SRC

ERBB4s80 binds to SRC

Stable Identifier

R-HSA-9612219

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SRC tyrosine kinase, activated by EGFR signaling, binds to the cleaved intracellular fragment of ERBB4, ERBB4s80 (E4ICD), released in response to ERBB4 activation by NRG1. Tyrosine phosphorylation of ERBB4s80 is needed for SRC binding. It is not clear whether tyrosine phosphorylation sites are auto-phosphorylated or phosphorylated by SRC. SRC binding prevents translocation of ERBB4s80 to the nucleus (Ishibashi et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23230144	Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src Ishibashi, K, Fukumoto, Y, Hasegawa, H, Abe, K, Kubota, S, Aoyama, K, Kubota, S, Nakayama, Y, Yamaguchi, N	J. Cell. Sci.	2013