EGR1, EGR2 bind the RRAD promoter

Stable Identifier
R-HSA-9613210
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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EGR1 and EGR2 are required for the activation of RRAD gene expression (Mager et al, 2008; Svaren et al, 2000). RRAD protein plays a role in serum-stimulated DNA synthesis in melanoma cells and contributes to electrical conductance in the heart (Zhu et al, 1999; Wang et al, 2010; Chang et al, 2007).

Literature References
PubMed ID Title Journal Year
18456662 Active gene repression by the Egr2.NAB complex during peripheral nerve myelination

Wrabetz, L, Mager, GM, Ward, RM, Svaren, J, Jang, SW, Srinivasan, R

J. Biol. Chem. 2008
10984481 EGR1 target genes in prostate carcinoma cells identified by microarray analysis

Watson, MA, Milbrandt, J, Ehrengruber, MU, Abdulkadir, SA, Svaren, J, Ehrig, T

J. Biol. Chem. 2000
10611312 Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

Kahn, CR, Zhu, J, Moyers, JS, Tseng, YH, Kantor, JD, Zetter, BR, Rhodes, CJ

Proc. Natl. Acad. Sci. U.S.A. 1999
19926875 Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart

Chen, C, Cheng, H, Wu, C, Wang, G, Song, R, Han, P, Cao, C, Xie, W, Li, K, Sun, Z, Zhu, X, Liu, J, Zhang, J, Wang, Y

Circ. Res. 2010
18056528 Rad GTPase deficiency leads to cardiac hypertrophy

Kahn, CR, Tseng, YH, Chang, L, Chen, YE, Ilany, J, Yang, Q, Cui, T, Sun, Z, BrĂ¼ning, JC, Day, SM, Zhu, X, Xie, CQ, Youker, KA, Zhang, J

Circulation 2007
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