Reactome | PLIN2 [lipid droplet]

PLIN2 [lipid droplet]

Stable Identifier

R-HSA-9613345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lipid droplet

Synonyms

Perilipin-2

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Locations in the PathwayBrowser for interactor UniProt:Q7Z3K3 POGZ

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Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        PLIN2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
        
        PLIN2 [lipid droplet] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99541 PLIN2

Gene Names

PLIN2, ADFP

Chain

initiator methionine:, chain:2-437

Reference Genes

BioGPS Gene:123 PLIN2

COSMIC (genes):PLIN2 PLIN2

CTD Gene:123 PLIN2

dbSNP Gene:123 PLIN2

ENSEMBL:ENSG00000147872 PLIN2

HGNC:248 PLIN2

KEGG:hsa:123 PLIN2

Monarch:123 PLIN2

NCBI Gene:123 PLIN2

OMIM:103195 PLIN2

UCSC:Q99541 PLIN2

Reference Transcript

RefSeq:NM_001122.3 PLIN2

Other Identifiers

11742745_a_at

11742746_a_at

123

209122_PM_at

209122_at

2436251

2436254

3200649

3200652

3200653

3200654

3200655

3200656

3200657

3200660

3200661

3200662

3200664

3200665

3200666

3200667

3200668

3200669

3200670

3200671

3200675

3200676

3200677

3200678

3200679

3200680

3200681

3200684

34378_at

8160297

A_21_P0014779

A_23_P134953

A_33_P3258617

GE60192

GE874376

GO:0005515

GO:0005576

GO:0005634

GO:0005737

GO:0005783

GO:0005811

GO:0005829

GO:0005886

GO:0009410

GO:0010890

GO:0014070

GO:0015909

GO:0016020

GO:0019915

GO:0042149

GO:0043226

GO:1905691

HMNXSV003010946

HMNXSV003011922

HMNXSV003041052

HMNXSV003041772

ILMN_1801077

ILMN_2138765

PH_hs_0000411

TC09000935.hg

TC09002418.hg

TC09002419.hg

X97324_at

g13477306_3p_at

Participates

as an output of

PLIN2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)

as a member of

PLINs on lipid droplet surface [lipid droplet] (Homo sapiens)

Other forms of this molecule

PLIN2 [plasma membrane]

p-PLIN2 [late endosome lumen]

p-PLIN2 [lipid droplet]

p-PLIN2 [cytosol]

p-PLIN2 [lysosomal lumen]

Cross References

RefSeq

NP_001113.2

ENSEMBL

ENST00000276914, ENSP00000276914

OpenTargets

ENSG00000147872

HPA

ENSG00000147872-PLIN2

PRO

Q99541

Pharos - Targets

Q99541

GlyGen

Q99541

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9BUP3-3 HTATIP2			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q7Z3K3 POGZ			0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:Q9BSY9 DESI2			0.556	3
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.556	3
UniProt:P0DTD8 NS7B			0.547	2

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