Unwinding DNA for the nascent transcript

Stable Identifier
R-HSA-9613497
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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The human BTF2 basic transcription factor (also called TFIIH), is required for class1 gene transcription of transcripts. TFIIH has an adenosine triphosphate-dependent DNA helicase activity. The helicase activity is closely associated with the multi-subunit BTF2/TFIIH transcription factor which also has a CTD protein kinase activity.

Literature References
PubMed ID Title Journal Year
8465201 DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

Schaeffer, L, Roy, R, Humbert, S, Moncollin, V, Vermeulen, W, Hoeijmakers, JH, Chambon, P, Egly, JM

Science 1993
11784853 Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape.

Kugel, JF, Goodrich, JA

Mol Cell Biol 2002
9405375 Three transitions in the RNA polymerase II transcription complex during initiation.

Holstege, FC, Fiedler, U, Timmers, HT

EMBO J 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3'-5' DNA helicase activity of TFIIH [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Created