Reactome | p-T32,S197,S262-FOXO4 [cytosol]

p-T32,S197,S262-FOXO4 [cytosol]

Stable Identifier

R-HSA-9614415

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FOXO4_HUMAN, FOXO4

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P98177 FOXO4

Gene Names

FOXO4, AFX, AFX1, MLLT7

Chain

chain:1-505

Reference Genes

BioGPS Gene:4303 FOXO4

COSMIC (genes):FOXO4 FOXO4

CTD Gene:4303 FOXO4

dbSNP Gene:4303 FOXO4

ENSEMBL:ENSG00000184481 FOXO4

HGNC:7139 FOXO4

KEGG Gene (Homo sapiens):4303 FOXO4

Monarch:4303 FOXO4

NCBI Gene:4303 FOXO4

OMIM:300033 FOXO4

UCSC:P98177 FOXO4

Reference Transcript

Other Identifiers

0001850671

11726862_a_at

11726863_at

11726864_x_at

11726865_a_at

11726866_at

11749238_a_at

11758631_s_at

17104578

205451_at

36238_at

3980746

3980747

3980748

3980749

3980750

3980753

3980754

3980755

3980757

4303

46743_s_at

8168205

A_14_P116918

A_23_P217487

A_24_P379165

A_33_P3249793

GE61886

GO:0000122

GO:0000228

GO:0000278

GO:0000790

GO:0000981

GO:0001228

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006355

GO:0006464

GO:0006950

GO:0007049

GO:0007050

GO:0007095

GO:0007165

GO:0007275

GO:0007517

GO:0007568

GO:0008013

GO:0008134

GO:0008150

GO:0008283

GO:0008285

GO:0008286

GO:0009058

GO:0014911

GO:0016525

GO:0016579

GO:0016607

GO:0019899

GO:0030154

GO:0031667

GO:0034641

GO:0040011

GO:0042592

GO:0042593

GO:0042802

GO:0043226

GO:0043565

GO:0045893

GO:0045944

GO:0048646

GO:0048856

GO:0048863

GO:0048870

GO:0051151

GO:0070317

GO:0071158

GO:1990785

GO:1990837

GO:1990841

ILMN_1712095

PH_hs_0026752

TC0X000381.hg

X93996_rna1_at

g5174578_3p_at

g5174578_3p_x_at

Participant Of

hasComponent

p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol]

input

14-3-3 proteins bind AKT-phosphorylated FOXO4

hasMember

p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol]

Other forms of this molecule

FOXO4 [nucleoplasm]

p-T32,S197,S262-FOXO4 [nucleoplasm]

SOH-C481-FOXO4 [nucleoplasm]

CREBBP-S-S-FOXO4 [nucleoplasm]

EP300-S-S-FOXO4 [nucleoplasm]

Ac-K-FOXO4 [nucleoplasm]

PolyUb-FOXO4 [nucleoplasm]

Inferred To

phospho-foxo [cytosol] (Drosophila melanogaster)

Homologues of p-T32,S197,S262-FOXO4 [cytosol] (Danio rerio)

phospho-foxo4 [cytosol] (Danio rerio)

phospho-foxo4 [cytosol] (Xenopus tropicalis)

phospho-foxo1b [cytosol] (Danio rerio)

phospho-FOXO4 [cytosol] (Bos taurus)

phospho-FOXO4 [cytosol] (Canis familiaris)

phospho-FOXO4 [cytosol] (Sus scrofa)

phospho-Foxo4 [cytosol] (Mus musculus)

phospho-Foxo4 [cytosol] (Rattus norvegicus)

phospho-daf-16 [cytosol] (Caenorhabditis elegans)

phospho-foxo1a [cytosol] (Danio rerio)

Modified Residues

Name

O-phospho-L-serine at 197

Coordinate

197

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 262

Coordinate

262

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 32

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001164402.1, NP_005929.2

OpenTargets

ENSG00000184481

HPA

ENSG00000184481-FOXO4

GeneCards

P98177

Ensembl

ENSP00000342209, ENSG00000184481, ENST00000374259, ENSP00000363377, ENST00000341558

PRO

P98177

PDB

3L2C, 1E17

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04864 REL	2	REL [nucleoplasm] (R-HSA-1168585) REL [cytosol] (R-HSA-1168579)	0.556	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.556	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	3
UniProt:Q13485 SMAD4	88	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 E417* [cytosol] (R-HSA-9675623) SMAD4 Y195* [cytosol] (R-HSA-9678462) SMAD4 E108* [cytosol] (R-HSA-9675640) SMAD4 S343* [cytosol] (R-HSA-9675641) SMAD4 E520* [cytosol] (R-HSA-9675636) SMAD4 G510* [cytosol] (R-HSA-9678452) SMAD4 G358* [cytosol] (R-HSA-9678453) SMAD4 E175* [cytosol] (R-HSA-9675637) SMAD4 E307* [cytosol] (R-HSA-9675639) SMAD4 E53* [cytosol] (R-HSA-9675633) SMAD4 S171* [cytosol] (R-HSA-9675634) SMAD4 G30* [cytosol] (R-HSA-9678450) SMAD4 G168* [cytosol] (R-HSA-9678451) SMAD4 Q366* [cytosol] (R-HSA-9675200) SMAD4 R135* [cytosol] (R-HSA-9675090) SMAD4 L146* [cytosol] (R-HSA-9678509) SMAD4 L440* [cytosol] (R-HSA-9678510) SMAD4 Q183* [cytosol] (R-HSA-9675176) SMAD4 Q289* [cytosol] (R-HSA-9675177) SMAD4 Q248* [cytosol] (R-HSA-9675178) SMAD4 Q249* [cytosol] (R-HSA-9675172) SMAD4 Q256* [cytosol] (R-HSA-9675173) SMAD4 Q239* [cytosol] (R-HSA-9675174) SMAD4 Q245* [cytosol] (R-HSA-9675175) SMAD4 Q224* [cytosol] (R-HSA-9675168) SMAD4 W509* [cytosol] (R-HSA-9678497) SMAD4 Q311* [cytosol] (R-HSA-9675169) SMAD4 W398* [cytosol] (R-HSA-9678498) SMAD4 Q250* [cytosol] (R-HSA-9675170) SMAD4 Q410* [cytosol] (R-HSA-9675196) SMAD4 Q534* [cytosol] (R-HSA-9675197) SMAD4 Q83* [cytosol] (R-HSA-9675199) SMAD4 Q448* [cytosol] (R-HSA-9675192) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 Q455* [cytosol] (R-HSA-9675193) SMAD4 R445* [cytosol] (R-HSA-9675065) SMAD4 Q442* [cytosol] (R-HSA-9675194) SMAD4 Q516* [cytosol] (R-HSA-9675195) SMAD4 C443* [cytosol] (R-HSA-9678523) SMAD4 Q334* [cytosol] (R-HSA-9675191) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 L172* [cytosol] (R-HSA-9678514) SMAD4 K122* [cytosol] (R-HSA-9678515) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 Y430* [cytosol] (R-HSA-9678476) SMAD4 Y260* [cytosol] (R-HSA-9678477) SMAD4 Y95* [cytosol] (R-HSA-9678478) SMAD4 Y322* [cytosol] (R-HSA-9678479) SMAD4 E321* [cytosol] (R-HSA-9675658) SMAD4 Y412* [cytosol] (R-HSA-9678469) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 Y328* [cytosol] (R-HSA-9678470) SMAD4 E33* [cytosol] (R-HSA-9675654) SMAD4 Y513* [cytosol] (R-HSA-9678471) SMAD4 E526* [cytosol] (R-HSA-9675648) SMAD4 S138* [cytosol] (R-HSA-9675649) SMAD4 Y276* [cytosol] (R-HSA-9678466) SMAD4 E205* [cytosol] (R-HSA-9675650) SMAD4 E49* [cytosol] (R-HSA-9675651) SMAD4 W101* [cytosol] (R-HSA-9678492) SMAD4 W268* [cytosol] (R-HSA-9678494) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 W524* [cytosol] (R-HSA-9678491) SMAD4 W302* [cytosol] (R-HSA-9678490) SMAD4 S242* [cytosol] (R-HSA-9675167) SMAD4 Q116* [cytosol] (R-HSA-9675166)	0.524	2
UniProt:P98177 FOXO4	8	p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501)	0.499	2

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