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p-T32,S197,S262-FOXO4 [cytosol]
Stable Identifier
R-HSA-9614415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FOXO4_HUMAN, FOXO4
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of localization of FOXO transcription factors (Homo sapiens)
14-3-3 proteins bind AKT-phosphorylated FOXO4 (Homo sapiens)
p-T32,S197,S262-FOXO4 [cytosol] (Homo sapiens)
p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol] (Homo sapiens)
p-T32,S197,S262-FOXO4 [cytosol] (Homo sapiens)
AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Homo sapiens)
p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol] (Homo sapiens)
p-T32,S197,S262-FOXO4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98177 FOXO4
Gene Names
FOXO4, AFX, AFX1, MLLT7
Chain
chain:1-505
Reference Genes
BioGPS Gene:4303 FOXO4
COSMIC (genes):FOXO4 FOXO4
CTD Gene:4303 FOXO4
dbSNP Gene:4303 FOXO4
ENSEMBL:ENSG00000184481 FOXO4
HGNC:7139 FOXO4
KEGG Gene (Homo sapiens):4303 FOXO4
Monarch:4303 FOXO4
NCBI Gene:4303 FOXO4
OMIM:300033 FOXO4
UCSC:P98177 FOXO4
Reference Transcript
RefSeq:NM_001170931.1 FOXO4
RefSeq:NM_005938.3 FOXO4
Other Identifiers
0001850671
11726862_a_at
11726863_at
11726864_x_at
11726865_a_at
11726866_at
11749238_a_at
11758631_s_at
17104578
205451_at
36238_at
3980746
3980747
3980748
3980749
3980750
3980753
3980754
3980755
3980757
4303
46743_s_at
8168205
A_14_P116918
A_23_P217487
A_24_P379165
A_33_P3249793
GE61886
GO:0000122
GO:0000228
GO:0000278
GO:0000790
GO:0000981
GO:0001228
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006464
GO:0006950
GO:0007049
GO:0007050
GO:0007095
GO:0007165
GO:0007275
GO:0007517
GO:0007568
GO:0008013
GO:0008134
GO:0008150
GO:0008283
GO:0008285
GO:0008286
GO:0009058
GO:0014911
GO:0016525
GO:0016579
GO:0016607
GO:0019899
GO:0030154
GO:0031667
GO:0034641
GO:0040011
GO:0042592
GO:0042593
GO:0042802
GO:0043226
GO:0043565
GO:0045893
GO:0045944
GO:0048646
GO:0048856
GO:0048863
GO:0048870
GO:0051151
GO:0070317
GO:0071158
GO:1990785
GO:1990837
GO:1990841
ILMN_1712095
PH_hs_0026752
TC0X000381.hg
X93996_rna1_at
g5174578_3p_at
g5174578_3p_x_at
Participant Of
hasComponent
p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol]
input
14-3-3 proteins bind AKT-phosphorylated FOXO4
hasMember
p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol]
Other forms of this molecule
FOXO4 [nucleoplasm]
p-T32,S197,S262-FOXO4 [nucleoplasm]
SOH-C481-FOXO4 [nucleoplasm]
CREBBP-S-S-FOXO4 [nucleoplasm]
EP300-S-S-FOXO4 [nucleoplasm]
Ac-K-FOXO4 [nucleoplasm]
PolyUb-FOXO4 [nucleoplasm]
Inferred To
phospho-foxo [cytosol] (Drosophila melanogaster)
Homologues of p-T32,S197,S262-FOXO4 [cytosol] (Danio rerio)
phospho-foxo4 [cytosol] (Danio rerio)
phospho-foxo4 [cytosol] (Xenopus tropicalis)
phospho-foxo1b [cytosol] (Danio rerio)
phospho-FOXO4 [cytosol] (Bos taurus)
phospho-FOXO4 [cytosol] (Canis familiaris)
phospho-FOXO4 [cytosol] (Sus scrofa)
phospho-Foxo4 [cytosol] (Mus musculus)
phospho-Foxo4 [cytosol] (Rattus norvegicus)
phospho-daf-16 [cytosol] (Caenorhabditis elegans)
phospho-foxo1a [cytosol] (Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 197
Coordinate
197
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 262
Coordinate
262
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 32
Coordinate
32
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001164402.1
,
NP_005929.2
OpenTargets
ENSG00000184481
HPA
ENSG00000184481-FOXO4
GeneCards
P98177
Ensembl
ENSP00000342209
,
ENSG00000184481
,
ENST00000374259
,
ENSP00000363377
,
ENST00000341558
PRO
P98177
PDB
3L2C
,
1E17
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04864 REL
2
REL [nucleoplasm]
(R-HSA-1168585)
REL [cytosol]
(R-HSA-1168579)
0.556
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.556
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.544
3
UniProt:Q13485 SMAD4
88
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
SMAD4 E417* [cytosol]
(R-HSA-9675623)
SMAD4 Y195* [cytosol]
(R-HSA-9678462)
SMAD4 E108* [cytosol]
(R-HSA-9675640)
SMAD4 S343* [cytosol]
(R-HSA-9675641)
SMAD4 E520* [cytosol]
(R-HSA-9675636)
SMAD4 G510* [cytosol]
(R-HSA-9678452)
SMAD4 G358* [cytosol]
(R-HSA-9678453)
SMAD4 E175* [cytosol]
(R-HSA-9675637)
SMAD4 E307* [cytosol]
(R-HSA-9675639)
SMAD4 E53* [cytosol]
(R-HSA-9675633)
SMAD4 S171* [cytosol]
(R-HSA-9675634)
SMAD4 G30* [cytosol]
(R-HSA-9678450)
SMAD4 G168* [cytosol]
(R-HSA-9678451)
SMAD4 Q366* [cytosol]
(R-HSA-9675200)
SMAD4 R135* [cytosol]
(R-HSA-9675090)
SMAD4 L146* [cytosol]
(R-HSA-9678509)
SMAD4 L440* [cytosol]
(R-HSA-9678510)
SMAD4 Q183* [cytosol]
(R-HSA-9675176)
SMAD4 Q289* [cytosol]
(R-HSA-9675177)
SMAD4 Q248* [cytosol]
(R-HSA-9675178)
SMAD4 Q249* [cytosol]
(R-HSA-9675172)
SMAD4 Q256* [cytosol]
(R-HSA-9675173)
SMAD4 Q239* [cytosol]
(R-HSA-9675174)
SMAD4 Q245* [cytosol]
(R-HSA-9675175)
SMAD4 Q224* [cytosol]
(R-HSA-9675168)
SMAD4 W509* [cytosol]
(R-HSA-9678497)
SMAD4 Q311* [cytosol]
(R-HSA-9675169)
SMAD4 W398* [cytosol]
(R-HSA-9678498)
SMAD4 Q250* [cytosol]
(R-HSA-9675170)
SMAD4 Q410* [cytosol]
(R-HSA-9675196)
SMAD4 Q534* [cytosol]
(R-HSA-9675197)
SMAD4 Q83* [cytosol]
(R-HSA-9675199)
SMAD4 Q448* [cytosol]
(R-HSA-9675192)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
SMAD4 Q455* [cytosol]
(R-HSA-9675193)
SMAD4 R445* [cytosol]
(R-HSA-9675065)
SMAD4 Q442* [cytosol]
(R-HSA-9675194)
SMAD4 Q516* [cytosol]
(R-HSA-9675195)
SMAD4 C443* [cytosol]
(R-HSA-9678523)
SMAD4 Q334* [cytosol]
(R-HSA-9675191)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 L172* [cytosol]
(R-HSA-9678514)
SMAD4 K122* [cytosol]
(R-HSA-9678515)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 Y430* [cytosol]
(R-HSA-9678476)
SMAD4 Y260* [cytosol]
(R-HSA-9678477)
SMAD4 Y95* [cytosol]
(R-HSA-9678478)
SMAD4 Y322* [cytosol]
(R-HSA-9678479)
SMAD4 E321* [cytosol]
(R-HSA-9675658)
SMAD4 Y412* [cytosol]
(R-HSA-9678469)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
SMAD4 Y328* [cytosol]
(R-HSA-9678470)
SMAD4 E33* [cytosol]
(R-HSA-9675654)
SMAD4 Y513* [cytosol]
(R-HSA-9678471)
SMAD4 E526* [cytosol]
(R-HSA-9675648)
SMAD4 S138* [cytosol]
(R-HSA-9675649)
SMAD4 Y276* [cytosol]
(R-HSA-9678466)
SMAD4 E205* [cytosol]
(R-HSA-9675650)
SMAD4 E49* [cytosol]
(R-HSA-9675651)
SMAD4 W101* [cytosol]
(R-HSA-9678492)
SMAD4 W268* [cytosol]
(R-HSA-9678494)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 W524* [cytosol]
(R-HSA-9678491)
SMAD4 W302* [cytosol]
(R-HSA-9678490)
SMAD4 S242* [cytosol]
(R-HSA-9675167)
SMAD4 Q116* [cytosol]
(R-HSA-9675166)
0.524
2
UniProt:P98177 FOXO4
8
p-T32,S197,S262-FOXO4 [nucleoplasm]
(R-HSA-199314)
FOXO4 [nucleoplasm]
(R-HSA-5690183)
p-T32,S197,S262-FOXO4 [cytosol]
(R-HSA-9614415)
SOH-C481-FOXO4 [nucleoplasm]
(R-HSA-9617655)
CREBBP-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617679)
EP300-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617681)
Ac-K-FOXO4 [nucleoplasm]
(R-HSA-9617761)
PolyUb-FOXO4 [nucleoplasm]
(R-HSA-6782501)
0.499
2
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