Reactome | EGR2, SOX10 and SMARCA4 bind the MPZ gene

EGR2, SOX10 and SMARCA4 bind the MPZ gene

Stable Identifier

R-HSA-9614790

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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EGR2, SOX10 and SMARCA4 bind the MPZ gene

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MPZ is a key component of the myelin sheath that surrounds axons of the peripheral nervous system. Expression of MPZ is dependent on binding of transcriptional regulators EGR2 and SOX10 to response elements in intron 1, where they recruit SMARCA4 to the gene (Le Blanc et al, 2006; Le Blanc et al, 2007; Marathe et al, 2013). SOX10 additionally binds to elements in the promoter of MPZ (Peirano et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
10757804	Protein zero gene expression is regulated by the glial transcription factor Sox10 Goerich, DE, Wegner, M, Riethmacher, D, Peirano, RI	Mol. Cell. Biol.	2000
23874858	SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression Yeung, KC, Datar, I, Zhang, X, Mehta, G, Marathe, HG, Mehrotra, A, de la Serna, IL	PLoS ONE	2013
17325040	Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10 Ward, RM, Svaren, J, Leblanc, SE	Mol. Cell. Biol.	2007
16373334	Direct regulation of myelin protein zero expression by the Egr2 transactivator Wrabetz, L, Ward, RM, Svaren, J, Jang, SW, Leblanc, SE	J. Biol. Chem.	2006