Latent Transcriptinally Repressed HCMV Genome

Stable Identifier
R-HSA-9614816
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
nucleoplasm
ReviewStatus
5/5
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Latent Transcriptinally Repressed HCMV Genome
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Cells infected by with the Human Cytomegalovirus (HCMV) have two potential fates once the HCMV genome enters the nucleus. In contrast, in a latent infection the lytic transcription programme of HCMV is effectively suppressed and the cells undergo latent infection. The suppression of viral lytic gene expression observed during latency is the result from the cells inability to support robust viral immediate early (IE) gene expression; crucial genes responsible for driving the lytic cycle. The repression of IE gene expression results from specific post-translational modifications of histones associated with the viral major immediate early promoter (MIEP). The histone modifications present on the MIEP impart a repressive chromatin structure preventing transcriptional activity.
In an active infection there is extensive viral gene expression, viral DNA replication and release of progeny virus.
Literature References
PubMed ID Title Journal Year
26572645 Cytomegalovirus latency and reactivation: recent insights into an age old problem

Reeves, MB, Dupont, L

Rev. Med. Virol. 2016
19682613 Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection

Sinclair, J

Biochim. Biophys. Acta 2010
30360396 HCMV miRNA Targets Reveal Important Cellular Pathways for Viral Replication, Latency, and Reactivation

Diggins, NL, Hancock, MH

Noncoding RNA 2018
  Fields Virology

Knipe, DM, Howley, PM

  2013
27501258 Human Cytomegalovirus Latency: Approaching the Gordian Knot

Goodrum, F

Annu Rev Virol 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TRIM28 [nucleoplasm] (Homo sapiens)
Regulator
UL111A [nucleoplasm] (Human cytomegalovirus)
Regulator
UL133 [nucleoplasm] (Human cytomegalovirus)
Regulator
UL138 [nucleoplasm] (Human cytomegalovirus)
Regulator
vRNA-2 [nucleoplasm] (Human cytomegalovirus)
Regulator
US28 [nucleoplasm] (Human cytomegalovirus)
Requirements
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Reviewed
Streblow, DN  (2019-10-18)
Caposio, P  (2019-10-18)
Created
Gillespie, ME  (2018-07-28)
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