Reactome | p-T26,S184-FOXO6 [nucleoplasm]

p-T26,S184-FOXO6 [nucleoplasm]

Stable Identifier

R-HSA-9614995

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - FOXO-mediated transcription (Homo sapiens)
      - Regulation of localization of FOXO transcription factors (Homo sapiens)
        
        AKT phosphorylates FOXO transcription factors (Homo sapiens)
        
        p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] (Homo sapiens)
        
        p-T26,S184-FOXO6 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - AKT phosphorylates targets in the nucleus (Homo sapiens)
      - AKT phosphorylates FOXO transcription factors (Homo sapiens)
        
        p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] (Homo sapiens)
        
        p-T26,S184-FOXO6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:A8MYZ6 FOXO6

Gene Names

FOXO6

Chain

chain:1-492

Reference Genes

COSMIC (genes):FOXO6 FOXO6

ENSEMBL:ENSG00000204060 FOXO6

ENSEMBL_homo_sapiens_GENE:ENSG00000204060.8 FOXO6

HGNC:24814 FOXO6

OMIM:611457 FOXO6

UCSC:A8MYZ6 FOXO6

Other Identifiers

100132074

16663199

2332249

2332250

2332277

2332278

2332279

2332280

2332281

2332282

2332283

2332284

2332285

239657_PM_x_at

239657_x_at

78353_i_at

78355_r_at

ADDON001228.hg

A_33_P3408752

A_33_P3408757

GO:0000785

GO:0000978

GO:0000981

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0007613

GO:0030154

GO:0043226

GO:0043565

GO:0048856

GO:0050877

GO:0060999

GO:0140110

HMNXSV003037101

Hs.133066.0.A1_3p_at

PH_hs_0034655

TC01000523.hg

Participates

as a candidate of

p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

FOXO6 [nucleoplasm]

Inferred To

phospho-Foxo6 [nucleoplasm] (Mus musculus)

phospho-Foxo6 [nucleoplasm] (Rattus norvegicus)

phospho-p-T26,S184-FOXO6 [nucleoplasm] (Gallus gallus)

phospho-FOXO6 [nucleoplasm] (Bos taurus)

phospho-FOXO6 [nucleoplasm] (Canis familiaris)

phospho-FOXO6 [nucleoplasm] (Sus scrofa)

phospho-foxo6 [nucleoplasm] (Danio rerio)

phospho-foxo [nucleoplasm] (Drosophila melanogaster)

phospho-daf-16 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-threonine at 26

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 184

Coordinate

184

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

OpenTargets

ENSG00000204060

HPA

ENSG00000204060-FOXO6

GeneCards

A8MYZ6

Ensembl

ENST00000641094, ENSP00000493184, ENSG00000204060

PRO

A8MYZ6

Pharos - Targets

A8MYZ6