Based on studies in mice, FOXO6 binds FOXO response elements in the PLXNA4 gene locus, encoding the semaphorin SEMA3A co-receptor PLXNA4. FOXO response elements are found in the promoter and the first intron of the mouse Plxna4 gene (Paap et al. 2016). The first intron of the human PLXNA4 gene contains several predicted FOXO response elements.
© 2021 Reactome