Reactome | PMP22 [plasma membrane]

PMP22 [plasma membrane]

Stable Identifier

R-HSA-9615623

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Peripheral myelin protein 22, PMP22_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q92838 EDA

Expand all

External Reference Information

External Reference

UniProt:Q01453 PMP22

Gene Names

PMP22, GAS3

Chain

chain:1-160

Reference Genes

BioGPS Gene:5376 PMP22

COSMIC (genes):PMP22 PMP22

CTD Gene:5376 PMP22

dbSNP Gene:5376 PMP22

ENSEMBL:ENSG00000109099 PMP22

ENSEMBL_homo_sapiens_GENE:ENSG00000109099.16 PMP22

HGNC:9118 PMP22

KEGG Gene (Homo sapiens):5376 PMP22

Monarch:5376 PMP22

NCBI Gene:5376 PMP22

OMIM:601097 PMP22

Reference Transcript

Other Identifiers

11715585_a_at

11728274_a_at

16841561

16841579

210139_PM_s_at

210139_s_at

3746575

3746576

3746587

3746588

3746593

3746596

3746597

3746598

3746599

3746603

3746604

3746605

3746613

38653_at

5376

73096_at

8012896

A_23_P100711

D11428_at

GE57050

GO:0005515

GO:0005886

GO:0005923

GO:0006915

GO:0007268

GO:0007422

GO:0008285

GO:0010977

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0032060

GO:0032288

GO:0042552

GO:0043218

GO:0045202

GO:0048856

HMNXSV003055957

ILMN_1659312

ILMN_1785646

ILMN_1810864

PH_hs_0024203

TC17001157.hg

TC17002504.hg

U08049_at

U08096_at

g182984_3p_a_at

Participates

as an output of

PMP22 gene expression (Homo sapiens)

Cross References

RefSeq

NP_001268385.1, NP_001268384.1, NP_696996.1, NP_696997.1, NP_000295.1

OpenTargets

ENSG00000109099

GeneCards

Q01453

HPA

ENSG00000109099-PMP22

Ensembl

ENST00000612492, ENST00000675819, ENST00000676221, ENST00000675808, ENSG00000109099, ENSP00000501804, ENST00000675350, ENST00000675950, ENST00000674673, ENST00000674651, ENSP00000502310, ENSP00000502018, ENSP00000502601, ENSP00000501546, ENSP00000501557, ENSP00000484631, ENSP00000501727, ENST00000312280, ENSP00000308937, ENST00000674868, ENSP00000502835

PRO

Q01453

Pharos - Targets

Q01453

Orphanet

15114

Interactors (59)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BZL3 SMIM3			0.805	9
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.718	6
UniProt:P40198 CEACAM3	2	CEACAM3 [specific granule membrane] (R-HSA-6806076) CEACAM3 [plasma membrane] (R-HSA-197706)	0.556	3
UniProt:Q9H3N1 TMX1			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q8IV31 TM139			0.556	3
UniProt:P56856 CLDN18	2	CLDN18 [plasma membrane] (R-HSA-432972) CLDN18 [cell junction] (R-HSA-434607)	0.556	3
UniProt:Q3SXP7 SHSL1			0.556	3
UniProt:P38484 IFNGR2	1	IFNGR2 [plasma membrane] (R-HSA-629620)	0.556	3
UniProt:P07307-3 ASGR2			0.556	3
UniProt:Q9NZD1 GPC5D			0.556	3
UniProt:Q16585 SGCB			0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:P48051 KCNJ6	1	KCNJ6 [plasma membrane] (R-HSA-975242)	0.556	3
UniProt:Q9GZW8 MS4A7			0.556	3
UniProt:O75787 ATP6AP2	3	ATP6AP2 [plasma membrane] (R-HSA-2022356) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921)	0.556	3
UniProt:Q07108 CD69			0.556	3
UniProt:Q6UWD8 CP054			0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:P56747 CLDN6	2	CLDN6 [plasma membrane] (R-HSA-419992) CLDN6 [cell junction] (R-HSA-421250)	0.556	3
UniProt:P19397 CD53	3	CD53 [specific granule membrane] (R-HSA-6804793) CD53 [plasma membrane] (R-HSA-6804817) CD53 [tertiary granule membrane] (R-HSA-6804799)	0.556	3
UniProt:P55899 FCGRN			0.556	3
UniProt:Q86T13 CLC14			0.556	3
UniProt:Q8N9I0 SYT2	3	SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [synaptic vesicle membrane] (R-HSA-194786)	0.556	3
UniProt:O95859 TSN12			0.556	3
UniProt:O43889-2 CREB3			0.556	3
UniProt:Q96DZ7 T4S19			0.556	3
UniProt:Q2HXU8-2 CLEC12B			0.556	3
UniProt:Q96HE8 TMM80			0.556	3
UniProt:Q3MIR4 CC50B			0.556	3
UniProt:P09693 CD3G	3	CD3G [clathrin-coated endocytic vesicle membrane] (R-HSA-8869080) CD3G [plasma membrane] (R-HSA-197917) p-Y160,Y171-CD3G [plasma membrane] (R-HSA-202362)	0.556	3
UniProt:Q9BZJ8 GPR61			0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:O95236-2 APOL3			0.556	3
UniProt:P41181 AQP2	3	AQP2 [transport vesicle membrane] (R-HSA-432215) p-S256-AQP2 [transport vesicle membrane] (R-HSA-432222) p-S256-AQP2 [plasma membrane] (R-HSA-432231)	0.556	3
UniProt:P35372-10 OPRM1			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P60508 SYCY2			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q96CE8 T4S18			0.556	3
UniProt:P31431 SDC4	20	SDC4 [lysosomal lumen] (R-HSA-2090041) HS(6)-SDC4 [lysosomal lumen] (R-HSA-2090058) HS(6)-SDC4 [Golgi lumen] (R-HSA-2076330) HS(5)-SDC4 [Golgi lumen] (R-HSA-2076510) Heparan-SDC4 [Golgi lumen] (R-HSA-2076374) Heparan(1)-SDC4 [Golgi lumen] (R-HSA-2076394) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064067) HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674) HS(5)-SDC4 [plasma membrane] (R-HSA-2076635)	0.556	3
UniProt:Q96MV1 TLCD4			0.556	3
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q9HBV2 SACA1			0.556	3
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.556	3
UniProt:P54219-3 P542193			0.556	3
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3

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