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Late endosomal microautophagy
Stable Identifier
R-HSA-9615710
DOI
10.3180/R-HSA-9615710.1
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
phagocytic vesicle
ReviewStatus
5/5
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Autophagy (Homo sapiens)
Late endosomal microautophagy (Homo sapiens)
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Microautophagy (MI) is a non-selective autophagic pathway that involves internalisation of cytosolic cargo through invaginations of the lysosomal membrane. MI can be induced by nitrogen starvation and complements other related self-eating processes such as Macroautophagy (MA) and Chaperone Mediated Autophagy (CMA). MI can degrade cell organelles and bulk cytosolic proteins directly via the lysosome and late endosome. MI can also target substrates with KFERQ motifs with the help of HSPA8 (Li W W et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
22080117
Microautophagy: lesser-known self-eating
Li, WW
,
Bao, JK
,
Li, J
Cell. Mol. Life Sci.
2012
Participants
Events
HSPA8 binds substrate
(Homo sapiens)
HSPA8:substrate binds late endosomal phospholipids
(Homo sapiens)
Substrate translocates into late endosomal lumen
(Homo sapiens)
Participates
as an event of
Autophagy (Homo sapiens)
Event Information
Go Biological Process
late endosomal microautophagy (0061738)
Cross References
BioModels Database
BIOMD0000000293
,
BIOMD0000000220
Authored
Varusai, TM (2019-02-21)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-08-08)
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