RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter

Stable Identifier
R-HSA-9616214
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter
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The evolutionarily conserved upstream enhancer of the CEBPA gene binds RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB in hemopoietic progenitor cells and myeloid progenitor cells (inferred from mouse). Unlike the promoter of the mouse Cebpa gene, the human CEBPA promoter does not bind CEBPA and autoregulation of CEBPA occurs indirectly through CEBPA-stimulated binding of USF to the promoter of the CEBPA gene (Timchenko et al. 1995). As inferred from mouse homologs, RUNX1, GATA2, SCL, SPI1, and FLI1 bind concomitantly.

Literature References
PubMed ID Title Journal Year
7862113 Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding

Timchenko, N, Wilson, DR, Taylor, LR, Abdelsayed, S, Wilde, M, Sawadogo, M, Darlington, GJ

Mol. Cell. Biol. 1995
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Runx1, Spi1, Gata2, Tal1, Fli1, Myb, and Cebpa bind the promoter of the Cebpa gene (Mus musculus)
Authored
May, B  (2018-08-09)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-08-09)