RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter

Stable Identifier
R-HSA-9616214
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The evolutionarily conserved upstream enhancer of the CEBPA gene binds RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB in hemopoietic progenitor cells and myeloid progenitor cells (inferred from mouse). Unlike the promoter of the mouse Cebpa gene, the human CEBPA promoter does not bind CEBPA and autoregulation of CEBPA occurs indirectly through CEBPA-stimulated binding of USF to the promoter of the CEBPA gene (Timchenko et al. 1995). As inferred from mouse homologs, RUNX1, GATA2, SCL, SPI1, and FLI1 bind concomitantly.

Literature References
PubMed ID Title Journal Year
7862113 Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding

Timchenko, N, Wilson, DR, Taylor, LR, Abdelsayed, S, Wilde, M, Sawadogo, M, Darlington, GJ

Mol. Cell. Biol. 1995
Participants
Input
Output
Participates
as an event of
Inferred From
Runx1, Spi1, Gata2, Tal1, Fli1, Myb, and Cebpa bind the promoter of the Cebpa gene (Mus musculus)
Authored
May, B  (2018-08-10)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-08-10)
Cite Us!