CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA

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R-HSA-9616243
Type
Reaction [BlackBoxEvent]
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Homo sapiens
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RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), MYB, and CEBPA itself all contribute to the level of transcription of CEBPA in hemopoietic progenitor cells and myeloid progenitor cells (inferred from mouse homologs). High levels of CEBPA appear to favor CEBPA:CEBPA homodimers and lead to granulopoiesis; low levels of CEBPA appear to favor CEBPA:AP-1 heterodimers and lead to monopoiesis. LEF1 also directly activates transcription of CEBPA (Skokowa et al. 2006, Skokowa et al. 2012), but appears to act at the transition of granulocyte-macrophage precursors to promyelocytes, a later stage of granulopoiesis.
The relative levels of SPI1 (PU.1) and CEBPA (SPI1 to CEBPA mRNA expression ratio) in granulocytic–macrophage progenitors have been suggested to regulate monocyte versus neutrophil cell-fate choice (Dahl et al. 2003).

Literature References
PubMed ID Title Journal Year
23001182 Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis

Skokowa, J, Klimiankou, M, Klimenkova, O, Lan, D, Gupta, K, Hussein, K, Carrizosa, E, Kusnetsova, I, Li, Z, Sustmann, C, Ganser, A, Zeidler, C, Kreipe, HH, Burkhardt, J, Grosschedl, R, Welte, K

Nat. Med. 2012
17063141 LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

Skokowa, J, Cario, G, Uenalan, M, Schambach, A, Germeshausen, M, Battmer, K, Zeidler, C, Lehmann, U, Eder, M, Baum, C, Grosschedl, R, Stanulla, M, Scherr, M, Welte, K

Nat. Med. 2006
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