SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene

Stable Identifier
R-HSA-9617064
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SPI1 (PU.1) binds the promoter of the CEBPE gene. PML (isoform 4) interacts with SPI1 and recruits the coactivator EP300 (p300) to SPI1 (Yoshida et al. 2007). The PML-RARA leukemogenic fusion protein dissociates the SPI1:PML:EP300 complex and inhibits transcription of CEBPE, thereby interfering with granulocyte differentiation (Yoshida et al. 2007).

Literature References
PubMed ID Title Journal Year
17562868 PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation

Yoshida, H, Ichikawa, H, Tagata, Y, Katsumoto, T, Ohnishi, K, Akao, Y, Naoe, T, Pandolfi, PP, Kitabayashi, I

Mol. Cell. Biol. 2007
Participants
Participant Of
Authored
Reviewed
Created